Design of carboxymethyl chitosan-reinforced pH-responsive hydrogels for on-demand release of carvacrol and simulation of release kinetics.
Food Chem
; 405(Pt A): 134856, 2023 Mar 30.
Article
en En
| MEDLINE
| ID: mdl-36368098
ABSTRACT
pH-responsive carboxymethyl chitosan (CC)/sodium alginate (SA)/carvacrol (CA) hydrogels were prepared using CC and SA as wall materials. The formation of hydrogels is attributed to electrostatic interactions and hydrogen bonding. The thermostability of the hydrogels was improved with increasing CC content. The swelling degree of the hydrogels increased with increasing pH of the buffer solution. The mechanism of CA release was mainly controlled by Fickian diffusion. Notably, the release rate of CA was positively correlated with temperature and environmental pH, thus the on-demand release of CA can be achieved through pH stimulation. The hydrogels showed good storage stability via determination of antioxidant and antibacterial activities. Furthermore, the C4S1-CA hydrogels (CC/SA blends with dry mass ratios of 41, w/w) have good biocompatibility and biosafety. The CC/SA/CA hydrogels provide a unique route for environmentally-responsive preservatives and present new avenues for precise release and intelligent preservation.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Hidrogeles
/
Quitosano
Idioma:
En
Revista:
Food Chem
Año:
2023
Tipo del documento:
Article
País de afiliación:
China