Time to surgery and survival in breast cancer.
BMC Surg
; 22(1): 388, 2022 Nov 11.
Article
en En
| MEDLINE
| ID: mdl-36369022
ABSTRACT
BACKGROUND:
This study aimed to investigate the effect of the time from diagnosis to breast cancer surgery on breast cancer patients' prognosis.METHODS:
Of the 1900 patients diagnosed with invasive (stage 1-3) breast cancer who underwent surgery in KUH between 2012 and 2019, 279 patients were enrolled in this study. All patients, including those who received neoadjuvant chemotherapy, were classified as Model 1 subjects, and those who received immediate surgical treatment were classified as Model 2 subjects. We conducted a Cox regression analysis to identify prognostic factors of breast cancer associated with the time from diagnosis to surgery.RESULTS:
The univariate results indicated a sharp drop in both groups' survival rates when the time to surgery was delayed for more than 8 weeks (Model 1 p = 0.000; Model 2 p = 0.001). In the multivariate analysis, the hazard ratio (HR) of Model 1increased (HR = 6.84, 95% CI 1.06-44.25) in response to a delay in surgery of more than 8 weeks. Smoking and the American Joint Committee on Cancer (AJCC) staging system had a negative effect on breast cancer prognosis, while hormone therapy had a positive effect.CONCLUSION:
For all patients, a delay in breast cancer surgery of more than 8 weeks was inversely associated with survival.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias de la Mama
Tipo de estudio:
Observational_studies
/
Prognostic_studies
Límite:
Female
/
Humans
Idioma:
En
Revista:
BMC Surg
Año:
2022
Tipo del documento:
Article