Globular glial tauopathy type II.
Pract Neurol
; 23(2): 153-156, 2023 Apr.
Article
en En
| MEDLINE
| ID: mdl-36411034
ABSTRACT
The globular glial tauopathies (GGTs) are a rare group of neurodegenerative diseases with fewer than 90 autopsy-confirmed cases reported in the literature. Although there has been some uncertainty about whether GGT is entirely distinct from progressive supranuclear palsy, a recent study of tau filament structures supports the definition of GGT as a separate neuropathological entity. We present a sporadic case of GGT type II presenting with a progressive corticobasal-primary lateral sclerosis overlap syndrome in a 74-year-old woman. Neuropathological examination identified neuronal and glial tau inclusions, including globular astrocytic and oligodendroglial inclusions. We also discuss the clinical features and molecular pathophysiology of GGT. Increased awareness of this condition could become more important as patients with GGT may be candidates for anti-tau therapies currently undergoing clinical evaluation in patients with other tauopathies.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Parálisis Supranuclear Progresiva
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Enfermedades Neurodegenerativas
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Tauopatías
Límite:
Aged
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Female
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Humans
Idioma:
En
Revista:
Pract Neurol
Año:
2023
Tipo del documento:
Article
País de afiliación:
Reino Unido