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Biotin Enhances Testosterone Production in Mice and Their Testis-Derived Cells.
Shiozawa, Kota; Maeda, Misato; Ho, Hsin-Jung; Katsurai, Tomoko; Howlader, Md Zakir Hossain; Horiuchi, Kimiko; Sugita, Yumi; Ohsaki, Yusuke; Agista, Afifah Zahra; Goto, Tomoko; Komai, Michio; Shirakawa, Hitoshi.
Afiliación
  • Shiozawa K; Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University, 468-1, Aramaki Aza Aoba, Aoba-ku, Sendai 980-8572, Japan.
  • Maeda M; Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University, 468-1, Aramaki Aza Aoba, Aoba-ku, Sendai 980-8572, Japan.
  • Ho HJ; Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University, 468-1, Aramaki Aza Aoba, Aoba-ku, Sendai 980-8572, Japan.
  • Katsurai T; Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University, 468-1, Aramaki Aza Aoba, Aoba-ku, Sendai 980-8572, Japan.
  • Howlader MZH; Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka 1000, Bangladesh.
  • Horiuchi K; Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University, 468-1, Aramaki Aza Aoba, Aoba-ku, Sendai 980-8572, Japan.
  • Sugita Y; Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University, 468-1, Aramaki Aza Aoba, Aoba-ku, Sendai 980-8572, Japan.
  • Ohsaki Y; Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University, 468-1, Aramaki Aza Aoba, Aoba-ku, Sendai 980-8572, Japan.
  • Agista AZ; International Education and Research Center for Food and Agricultural Immunology, Graduate School of Agricultural Science, Tohoku University, 468-1, Aramaki Aza Aoba, Aoba-ku, Sendai 980-8572, Japan.
  • Goto T; Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University, 468-1, Aramaki Aza Aoba, Aoba-ku, Sendai 980-8572, Japan.
  • Komai M; Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University, 468-1, Aramaki Aza Aoba, Aoba-ku, Sendai 980-8572, Japan.
  • Shirakawa H; Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University, 468-1, Aramaki Aza Aoba, Aoba-ku, Sendai 980-8572, Japan.
Nutrients ; 14(22)2022 Nov 10.
Article en En | MEDLINE | ID: mdl-36432448
Late-onset hypogonadism, a male age-related syndrome characterized by a decline in testosterone production in the testes, is commonly treated with testosterone replacement therapy, which has adverse side effects. Therefore, an alternative treatment is highly sought. Supplementation of a high dosage of biotin, a water-soluble vitamin that functions as a coenzyme for carboxylases involved in carbohydrate, lipid, and amino acid metabolism, has been shown to influence testis functions. However, the involvement of biotin in testis steroidogenesis has not been well clarified. In this study, we examined the effect of biotin on testosterone levels in mice and testis-derived cells. In mice, intraperitoneal treatment with biotin (1.5 mg/kg body weight) enhanced testosterone levels in the serum and testes, without elevating serum levels of pituitary luteinizing hormone. To investigate the mechanism in which biotin increased the testosterone level, mice testis-derived I-10 cells were used. The cells treated with biotin increased testosterone production in a dose- and time-dependent manner. Biotin treatment elevated intracellular cyclic adenosine monophosphate levels via adenylate cyclase activation, followed by the activation of protein kinase A and testosterone production. These results suggest that biotin may have the potential to improve age-related male syndromes associated with declining testosterone production.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Testículo / Testosterona Límite: Animals Idioma: En Revista: Nutrients Año: 2022 Tipo del documento: Article País de afiliación: Japón

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Testículo / Testosterona Límite: Animals Idioma: En Revista: Nutrients Año: 2022 Tipo del documento: Article País de afiliación: Japón