Your browser doesn't support javascript.
loading
Usefulness of ultrasound guided core needle biopsy of the parotid gland for the diagnosis of primary Sjögren's syndrome.
Zabotti, Alen; Pegolo, Enrico; Giovannini, Ivan; Manfrè, Valeria; Lorenzon, Michele; Hocevar, Alojzija; Zandonella Callegher, Sara; Dejaco, Christian; Quartuccio, Luca; Di Loreto, Carla; Zuiani, Chiara; De Vita, Salvatore.
Afiliación
  • Zabotti A; Rheumatology Clinic, Department of Medicine, Azienda Sanitaria Universitaria Friuli Centrale c/o University of Udine, Italy.
  • Pegolo E; Institute of Anatomic Pathology, Azienda Sanitaria Universitaria Friuli Centrale c/o University of Udine, Italy.
  • Giovannini I; Rheumatology Clinic, Department of Medicine, Azienda Sanitaria Universitaria Friuli Centrale c/o University of Udine, Italy.
  • Manfrè V; Rheumatology Clinic, Department of Medicine, Azienda Sanitaria Universitaria Friuli Centrale c/o University of Udine, Italy.
  • Lorenzon M; Institute of Radiology, Azienda Sanitaria Universitaria Friuli Centrale c/o University of Udine, Italy.
  • Hocevar A; Department of Rheumatology, University Medical Centre Ljubljana, Slovenia.
  • Zandonella Callegher S; Rheumatology Clinic, Department of Medicine, Azienda Sanitaria Universitaria Friuli Centrale c/o University of Udine, Italy.
  • Dejaco C; Department of Rheumatology, Hospital of Bruneck, Italy.
  • Quartuccio L; Rheumatology Clinic, Department of Medicine, Azienda Sanitaria Universitaria Friuli Centrale c/o University of Udine, Italy.
  • Di Loreto C; Institute of Anatomic Pathology, Azienda Sanitaria Universitaria Friuli Centrale c/o University of Udine, Italy.
  • Zuiani C; Institute of Radiology, Azienda Sanitaria Universitaria Friuli Centrale c/o University of Udine, Italy.
  • De Vita S; Rheumatology Clinic, Department of Medicine, Azienda Sanitaria Universitaria Friuli Centrale c/o University of Udine, Italy. salvatore.devita@asufc.sanita.fvg.it.
Clin Exp Rheumatol ; 40(12): 2381-2386, 2022 Dec.
Article en En | MEDLINE | ID: mdl-36441652
OBJECTIVES: The diagnosis and classification of primary Sjögren's syndrome (pSS) relies on labial biopsy, whereas the role of open parotid biopsy is mainly reserved to evaluate the lymphoproliferative complications. Recently ultrasound-guided core needle biopsy (US-guided CNB) appeared as a novel and safe technique useful in lymphoma assessment, however, its potential role in the diagnosis of pSS has never been assessed.The main aim of this study was to evaluate the diagnostic value of US-guided CNB of the parotid glands in patients affected by pSS. METHODS: Patients affected by pSS who underwent US-guided CNB for a suspected glandular lymphoma were included. Adequacy of the samples and histopathological features related to pSS were analysed. RESULTS: US-guided CNB was performed on 29 parotid glands. The biopsied samples were adequate for diagnosis in 28/29 (96.5%) cases. Fifteen patients showed pathologic features of parotid lymphoma. Among the remaining patients, 9/13 presented focus score≥1; LELs were present in 8/13 patients, and GCs in 11/13. In 8 cases the histological features were coherent with MESA/LESA. Acinar atrophy, fibrosis and duct dilatation were also evaluated. CONCLUSIONS: This preliminary study suggests the possible usefulness of US-guided CNB for the diagnosis of pSS by enabling the collection of adequate salivary gland tissue to assess the FS, GCs, LELs, and other histopathologic features also useful in the management of pSS patients.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias de la Parótida / Síndrome de Sjögren / Linfoma Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: Clin Exp Rheumatol Año: 2022 Tipo del documento: Article País de afiliación: Italia

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias de la Parótida / Síndrome de Sjögren / Linfoma Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: Clin Exp Rheumatol Año: 2022 Tipo del documento: Article País de afiliación: Italia