Design, synthesis, and metabolite identification of Tamoxifen esterase-activatable prodrugs.

Elbagoury, Rahma M; Shenouda, Miriam A; Elnakib, Heba E; Wober, Jannette; Abadi, Ashraf H; Ahmed, Nermin S

Elbagoury, Rahma M; Shenouda, Miriam A; Elnakib, Heba E; Wober, Jannette; Abadi, Ashraf H; Ahmed, Nermin S.

Afiliación

Elbagoury RM; Faculty of Pharmacy and Biotechnology, Department of Pharmaceutical Chemistry, German University in Cairo, Cairo, Egypt.
Shenouda MA; Faculty of Pharmacy and Biotechnology, Department of Pharmaceutical Chemistry, German University in Cairo, Cairo, Egypt.
Elnakib HE; Faculty of Pharmacy and Biotechnology, Department of Pharmaceutical Chemistry, German University in Cairo, Cairo, Egypt.
Wober J; Faculty of Biology, Institute of Zoology, Technische Universität Dresden, 01062 Dresden, Germany.
Abadi AH; Faculty of Pharmacy and Biotechnology, Department of Pharmaceutical Chemistry, German University in Cairo, Cairo, Egypt.
Ahmed NS; Faculty of Pharmacy and Biotechnology, Department of Pharmaceutical Chemistry, German University in Cairo, Cairo, Egypt. Electronic address: nermin.salah@guc.edu.eg.

Bioorg Chem ; 131: 106303, 2023 02.

Article en En | MEDLINE | ID: mdl-36455483

Asunto(s)

Neoplasias de la Mama; Profármacos; Femenino; Humanos; Tamoxifeno/farmacología; Profármacos/farmacología; Profármacos/uso terapéutico; Esterasas; Antagonistas de Estrógenos; Neoplasias de la Mama/tratamiento farmacológico; Neoplasias de la Mama/metabolismo; Citocromo P-450 CYP2D6/metabolismo

Palabras clave

CYP2D6; Flexible; MCF-7; Poor metabolizers; Supersomes; Tamoxifen

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Profármacos Tipo de estudio: Diagnostic_studies Límite: Female / Humans Idioma: En Revista: Bioorg Chem Año: 2023 Tipo del documento: Article País de afiliación: Egipto

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