A Plasmodium falciparum ubiquitin-specific protease (PfUSP) is essential for parasite survival and its disruption enhances artemisinin efficacy.

Arora, Priya; Narwal, Monika; Thakur, Vandana; Mukhtar, Osama; Malhotra, Pawan; Mohmmed, Asif

Arora, Priya; Narwal, Monika; Thakur, Vandana; Mukhtar, Osama; Malhotra, Pawan; Mohmmed, Asif.

Afiliación

Arora P; International Centre for Genetic Engineering and Biotechnology, New Delhi 110 067, India.
Narwal M; International Centre for Genetic Engineering and Biotechnology, New Delhi 110 067, India.
Thakur V; International Centre for Genetic Engineering and Biotechnology, New Delhi 110 067, India.
Mukhtar O; International Centre for Genetic Engineering and Biotechnology, New Delhi 110 067, India.
Malhotra P; International Centre for Genetic Engineering and Biotechnology, New Delhi 110 067, India.
Mohmmed A; International Centre for Genetic Engineering and Biotechnology, New Delhi 110 067, India.

Biochem J ; 480(1): 25-39, 2023 01 13.

Article en En | MEDLINE | ID: mdl-36511651

Asunto(s)

Antimaláricos; Artemisininas; Malaria; Parásitos; Humanos; Animales; Plasmodium falciparum/metabolismo; Complejo de la Endopetidasa Proteasomal/genética; Complejo de la Endopetidasa Proteasomal/metabolismo; Proteasas Ubiquitina-Específicas/metabolismo; Proteasas Ubiquitina-Específicas/farmacología; Artemisininas/farmacología; Artemisininas/metabolismo; Antimaláricos/química; Ubiquitina/genética; Ubiquitina/metabolismo; Resistencia a Medicamentos/genética

Palabras clave

Plasmodium falciparum; artemisinin resistance; deubiquitinase; malaria; organelle homeostasis

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Parásitos / Artemisininas / Malaria / Antimaláricos Límite: Animals / Humans Idioma: En Revista: Biochem J Año: 2023 Tipo del documento: Article País de afiliación: India

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google