Data on cardiac lncRNA STX18-AS1 expression in developing human hearts and function during in vitro hESC-cardiomyocyte differentiation.
Data Brief
; 45: 108770, 2022 Dec.
Article
en En
| MEDLINE
| ID: mdl-36533287
ABSTRACT
This article presents data concerning STX18-AS1, a long noncoding RNA gene identified from a Genome-wide association study of Atrial Septal Defect (ASD). The data describes its expression patterns in human tissues and functions in regulating cardiomyocyte differentiation in vitro. STX18-AS1 is a lncRNA with a higher abundance in developing tissues, including hearts. Its transcription distribution within the embryonic hearts during key heart septation stages supports STX18-AS1's association with risk SNPs for ASD. The CRISPR stem cell pool in which STX18-AS1 was knocked down, showed reduced CM differentiation efficiency and lower expression of key cardiac transcriptional factors. This indicated its regulative role in supporting the lineage specification from cardiac mesoderm into cardiac progenitors and cardiomyocytes. These data can benefit the understanding of human embryonic heart developmental biology, and the time-course changes of cardiac transcriptional factors during in vitro cardiomyocyte differentiation from human embryonic stem cells.
ASD, Atrial Septal Defect; CM, Cardiomyocyte; CRISPR; Cardiac development; Cardiomyocyte differentiation; GWAS, Genome-Wide Association Study; Human heart; Long noncoding RNA; SNP, Single Nucleotide Polymorphism; Time-course; eQTL, Expression Quantitative Trait Loci; hESC, human Embryonic Stem Cell; lncRNA, long noncoding RNA
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Data Brief
Año:
2022
Tipo del documento:
Article
País de afiliación:
Reino Unido