Immunomodulation of HDAC Inhibitor Entinostat Potentiates the Anticancer Effects of Radiation and PD-1 Blockade in the Murine Lewis Lung Carcinoma Model.

Kim, Yeeun; Park, Kyunghee; Kim, Yeon Jeong; Shin, Sung-Won; Kim, Yeon Joo; Choi, Changhoon; Noh, Jae Myoung

Kim, Yeeun; Park, Kyunghee; Kim, Yeon Jeong; Shin, Sung-Won; Kim, Yeon Joo; Choi, Changhoon; Noh, Jae Myoung.

Afiliación

Kim Y; Department of Radiation Oncology, Samsung Medical Center, Seoul 06351, Republic of Korea.
Park K; Samsung Genome Institute, Samsung Medical Center, Seoul 06351, Republic of Korea.
Kim YJ; Samsung Genome Institute, Samsung Medical Center, Seoul 06351, Republic of Korea.
Shin SW; Department of Radiation Oncology, Samsung Medical Center, Seoul 06351, Republic of Korea.
Kim YJ; Department of Radiation Oncology, Samsung Medical Center, Seoul 06351, Republic of Korea.
Choi C; Department of Radiation Oncology, Samsung Medical Center, Seoul 06351, Republic of Korea.
Noh JM; Department of Radiation Oncology, Samsung Medical Center, Seoul 06351, Republic of Korea.

Int J Mol Sci ; 23(24)2022 Dec 08.

Article en En | MEDLINE | ID: mdl-36555180

Asunto(s)

Carcinoma Pulmonar de Lewis; Inhibidores de Histona Desacetilasas; Animales; Ratones; Inhibidores de Histona Desacetilasas/farmacología; Inhibidores de Histona Desacetilasas/uso terapéutico; Linfocitos T CD8-positivos; Carcinoma Pulmonar de Lewis/tratamiento farmacológico; Inmunomodulación; Inmunidad; Interferón gamma/farmacología; Línea Celular Tumoral; Microambiente Tumoral

Palabras clave

anti-PD-1; antitumor immunity; entinostat; lung cancer; radiation

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Carcinoma Pulmonar de Lewis / Inhibidores de Histona Desacetilasas Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Int J Mol Sci Año: 2022 Tipo del documento: Article

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