Factors Predicting Long-term Estimated Glomerular Filtration Rate Decrease, a Reliable Indicator of Renal Function After Adrenalectomy in Primary Aldosteronism.
Endocr Pract
; 29(3): 199-205, 2023 Mar.
Article
en En
| MEDLINE
| ID: mdl-36563786
ABSTRACT
OBJECTIVE:
The long-term decrease in estimated glomerular filtration rate (eGFR) in patients with primary aldosteronism (PA) after adrenalectomy may be influenced by multiple preoperative factors. The present study aimed to provide a systematic review and meta-analysis of these factors.METHODS:
A systematic literature search was conducted to determine eligible observational studies on the possible association between preoperative factors and postoperative long-term eGFR decrease in patients with PA using PubMed, Web of Science, Embase, and Cochrane Library databases.RESULTS:
A total of 8 relevant studies with 1159 patients were included. Old age (odds ratio [OR] = 1.05, 95% CI 1.02-1.09, P = .001), high systolic blood pressure (OR = 1.05, 95% CI 1.01-1.09, P = .01), baseline hypokalemia (OR = 0.08, 95% CI 0.02-0.30, P < .001), and low eGFR (OR = 0.92, 95% CI 0.87-0.97, P = .001) presented a strong association with long-term eGFR decrease after adrenalectomy.CONCLUSION:
We provide evidence that old age, high systolic blood pressure, baseline hypokalemia, and low eGFR are associated with an increased risk of postoperative long-term eGFR decrease in patients with PA postoperatively. More attention should be given to the above factors for the timely prevention and management of renal impairment.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Hiperaldosteronismo
/
Hipopotasemia
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Systematic_reviews
Límite:
Humans
Idioma:
En
Revista:
Endocr Pract
Asunto de la revista:
ENDOCRINOLOGIA
Año:
2023
Tipo del documento:
Article
País de afiliación:
China