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Complete Tolerogenic Adjuvant Stimulates Regulatory T Cell Response to Immunization.
Zheng, Guoxing; Geng, Yajun; Yan, Zhaoqi; Shin, Soo Min; Joshi, Kanak; Panicker, Anjali; Shankar, Archana; Elangovan, Ramya; Koehler, Jason; Gnanasekar, Varun; Gilles, Jessica Ann; Munirathinam, Gnanasekar; Chen, Aoshuang.
Afiliación
  • Zheng G; Department of Biomedical Sciences, University of Illinois College of Medicine Rockford, Rockford, IL; and.
  • Geng Y; Department of Biomedical Sciences, University of Illinois College of Medicine Rockford, Rockford, IL; and.
  • Yan Z; Department of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Shin SM; Department of Biomedical Sciences, University of Illinois College of Medicine Rockford, Rockford, IL; and.
  • Joshi K; Department of Biomedical Sciences, University of Illinois College of Medicine Rockford, Rockford, IL; and.
  • Panicker A; Department of Biomedical Sciences, University of Illinois College of Medicine Rockford, Rockford, IL; and.
  • Shankar A; Department of Biomedical Sciences, University of Illinois College of Medicine Rockford, Rockford, IL; and.
  • Elangovan R; Department of Biomedical Sciences, University of Illinois College of Medicine Rockford, Rockford, IL; and.
  • Koehler J; Department of Biomedical Sciences, University of Illinois College of Medicine Rockford, Rockford, IL; and.
  • Gnanasekar V; Department of Biomedical Sciences, University of Illinois College of Medicine Rockford, Rockford, IL; and.
  • Gilles JA; Department of Biomedical Sciences, University of Illinois College of Medicine Rockford, Rockford, IL; and.
  • Munirathinam G; Department of Biomedical Sciences, University of Illinois College of Medicine Rockford, Rockford, IL; and.
  • Chen A; Department of Biomedical Sciences, University of Illinois College of Medicine Rockford, Rockford, IL; and.
J Immunol ; 210(5): 609-617, 2023 03 01.
Article en En | MEDLINE | ID: mdl-36602931
ABSTRACT
We have determined in mice the minimum composition required for forming a vaccine adjuvant that stimulates a regulatory T (Treg) cell response to immunization, and we named the adjuvant "complete tolerogenic adjuvant." This new kind of adjuvant may let us use the well-proven "Ag with adjuvant" form of immunization for inducing Treg cell-mediated Ag-specific immunosuppression. The minimum composition consists of dexamethasone, rapamycin, and monophosphoryl lipid A at a mass ratio of 8203. By dissecting the respective role of each of these components during immunization, we have further shown why immunosuppressive and immunogenic agents are both needed for forming true adjuvants for Treg cells. This finding may guide the design of additional, and potentially more potent, complete tolerogenic adjuvants with which we may form numerous novel vaccines for treating immune diseases.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Vacunas / Linfocitos T Reguladores Límite: Animals Idioma: En Revista: J Immunol Año: 2023 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Vacunas / Linfocitos T Reguladores Límite: Animals Idioma: En Revista: J Immunol Año: 2023 Tipo del documento: Article