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Novel integrative elements and genomic plasticity in ocean ecosystems.
Hackl, Thomas; Laurenceau, Raphaël; Ankenbrand, Markus J; Bliem, Christina; Cariani, Zev; Thomas, Elaina; Dooley, Keven D; Arellano, Aldo A; Hogle, Shane L; Berube, Paul; Leventhal, Gabriel E; Luo, Elaine; Eppley, John M; Zayed, Ahmed A; Beaulaurier, John; Stepanauskas, Ramunas; Sullivan, Matthew B; DeLong, Edward F; Biller, Steven J; Chisholm, Sallie W.
Afiliación
  • Hackl T; Massachusetts Institute of Technology, Department of Civil and Environmental Engineering, Cambridge, MA 02139, USA; Groningen Institute for Evolutionary Life Sciences, University of Groningen, 9700CC Groningen, the Netherlands. Electronic address: t.hackl@rug.nl.
  • Laurenceau R; Massachusetts Institute of Technology, Department of Civil and Environmental Engineering, Cambridge, MA 02139, USA.
  • Ankenbrand MJ; Massachusetts Institute of Technology, Department of Civil and Environmental Engineering, Cambridge, MA 02139, USA; University of Würzburg, Center for Computational and Theoretical Biology, 97070 Würzburg, Germany.
  • Bliem C; Massachusetts Institute of Technology, Department of Civil and Environmental Engineering, Cambridge, MA 02139, USA.
  • Cariani Z; Massachusetts Institute of Technology, Department of Civil and Environmental Engineering, Cambridge, MA 02139, USA.
  • Thomas E; Massachusetts Institute of Technology, Department of Civil and Environmental Engineering, Cambridge, MA 02139, USA.
  • Dooley KD; Massachusetts Institute of Technology, Department of Civil and Environmental Engineering, Cambridge, MA 02139, USA.
  • Arellano AA; Massachusetts Institute of Technology, Department of Civil and Environmental Engineering, Cambridge, MA 02139, USA.
  • Hogle SL; Massachusetts Institute of Technology, Department of Civil and Environmental Engineering, Cambridge, MA 02139, USA.
  • Berube P; Massachusetts Institute of Technology, Department of Civil and Environmental Engineering, Cambridge, MA 02139, USA.
  • Leventhal GE; Massachusetts Institute of Technology, Department of Civil and Environmental Engineering, Cambridge, MA 02139, USA.
  • Luo E; Daniel K. Inouye Center for Microbial Oceanography, Research and Education, University of Hawai'i Manoa, Honolulu, HI 96822, USA.
  • Eppley JM; Daniel K. Inouye Center for Microbial Oceanography, Research and Education, University of Hawai'i Manoa, Honolulu, HI 96822, USA.
  • Zayed AA; EMERGE Biology Integration Institute, Ohio State University, Columbus, OH 43210, USA; Center of Microbiome Science, Ohio State University, Columbus, OH 43210, USA.
  • Beaulaurier J; Oxford Nanopore Technologies Inc, San Francisco, CA 94501, USA.
  • Stepanauskas R; Bigelow Laboratory for Ocean Sciences, East Boothbay, ME 04544, USA.
  • Sullivan MB; Department of Microbiology & Department of Civil, Environmental, and Geodetic Engineering, Ohio State University, Columbus, OH 43210, USA; EMERGE Biology Integration Institute, Ohio State University, Columbus, OH 43210, USA; Center of Microbiome Science, Ohio State University, Columbus, OH 43210
  • DeLong EF; Daniel K. Inouye Center for Microbial Oceanography, Research and Education, University of Hawai'i Manoa, Honolulu, HI 96822, USA.
  • Biller SJ; Wellesley College, Department of Biological Sciences, Wellesley, MA 02481, USA.
  • Chisholm SW; Massachusetts Institute of Technology, Department of Civil and Environmental Engineering, Cambridge, MA 02139, USA; Massachusetts Institute of Technology, Department of Biology, Cambridge, MA 02139, USA. Electronic address: chisholm@mit.edu.
Cell ; 186(1): 47-62.e16, 2023 01 05.
Article en En | MEDLINE | ID: mdl-36608657
ABSTRACT
Horizontal gene transfer accelerates microbial evolution. The marine picocyanobacterium Prochlorococcus exhibits high genomic plasticity, yet the underlying mechanisms are elusive. Here, we report a novel family of DNA transposons-"tycheposons"-some of which are viral satellites while others carry cargo, such as nutrient-acquisition genes, which shape the genetic variability in this globally abundant genus. Tycheposons share distinctive mobile-lifecycle-linked hallmark genes, including a deep-branching site-specific tyrosine recombinase. Their excision and integration at tRNA genes appear to drive the remodeling of genomic islands-key reservoirs for flexible genes in bacteria. In a selection experiment, tycheposons harboring a nitrate assimilation cassette were dynamically gained and lost, thereby promoting chromosomal rearrangements and host adaptation. Vesicles and phage particles harvested from seawater are enriched in tycheposons, providing a means for their dispersal in the wild. Similar elements are found in microbes co-occurring with Prochlorococcus, suggesting a common mechanism for microbial diversification in the vast oligotrophic oceans.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Genoma Bacteriano / Ecosistema Idioma: En Revista: Cell Año: 2023 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Genoma Bacteriano / Ecosistema Idioma: En Revista: Cell Año: 2023 Tipo del documento: Article