Why Is Rapamycin Not a Rapalog?
Gerontology
; 69(6): 657-659, 2023.
Article
en En
| MEDLINE
| ID: mdl-36617414
ABSTRACT
Rapamycin (sirolimus) is an immunosuppressive drug approved by the Food and Drug Administration (FDA). It is also a leading candidate for targeting aging. Rapamycin and its analogs (everolimus, temsirolimus, ridaforolimus) inhibit the mammalian target of rapamycin (mTOR) kinase by binding to FK506-binding proteins (FKBP) and have a similar chemical structure that only differs in the functional group present at carbon-40. Analogs of rapamycin were developed to improve its pharmacological properties, such as low oral bioavailability and a long half-life. The analogs of rapamycin are referred to as "rapalogs." Rapamycin is the parent compound and should therewith not be called a "rapalog."
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Sirolimus
/
Inhibidores mTOR
Límite:
Humans
Idioma:
En
Revista:
Gerontology
Año:
2023
Tipo del documento:
Article