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Natural and synthetic 2-oxoglutarate derivatives are substrates for oncogenic variants of human isocitrate dehydrogenase 1 and 2.
Liu, Xiao; Reinbold, Raphael; Liu, Shuang; Herold, Ryan A; Rabe, Patrick; Duclos, Stéphanie; Yadav, Rahul B; Abboud, Martine I; Thieffine, Sandrine; Armstrong, Fraser A; Brewitz, Lennart; Schofield, Christopher J.
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  • Liu X; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, United Kingdom.
  • Reinbold R; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, United Kingdom.
  • Liu S; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, United Kingdom.
  • Herold RA; Inorganic Chemistry Laboratory, Department of Chemistry, University of Oxford, Oxford, United Kingdom.
  • Rabe P; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, United Kingdom.
  • Duclos S; Evotec (UK) Ltd, Abingdon, United Kingdom.
  • Yadav RB; Evotec (UK) Ltd, Abingdon, United Kingdom.
  • Abboud MI; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, United Kingdom.
  • Thieffine S; Evotec (US) Inc., Princeton, NJ, USA.
  • Armstrong FA; Inorganic Chemistry Laboratory, Department of Chemistry, University of Oxford, Oxford, United Kingdom.
  • Brewitz L; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, United Kingdom. Electronic address: lennart.brewitz@chem.ox.ac.uk.
  • Schofield CJ; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, United Kingdom. Electronic address: christopher.schofield@chem.ox.ac.uk.
J Biol Chem ; 299(2): 102873, 2023 02.
Article en En | MEDLINE | ID: mdl-36621625
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Isocitrato Deshidrogenasa / Ácidos Cetoglutáricos Límite: Humans Idioma: En Revista: J Biol Chem Año: 2023 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
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PubMed Links
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Isocitrato Deshidrogenasa / Ácidos Cetoglutáricos Límite: Humans Idioma: En Revista: J Biol Chem Año: 2023 Tipo del documento: Article País de afiliación: Reino Unido