Ginsenoside 3ß-O-Glc-DM (C3DM) suppressed glioma tumor growth by downregulating the EGFR/PI3K/AKT/mTOR signaling pathway and modulating the tumor microenvironment.

Tang, Mei; Deng, Haidong; Zheng, Kailu; He, Jiuming; Yang, Jinling; Li, Yan

Tang, Mei; Deng, Haidong; Zheng, Kailu; He, Jiuming; Yang, Jinling; Li, Yan.

Afiliación

Tang M; Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Institute of Material Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Deng H; Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Institute of Material Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Zheng K; Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Institute of Material Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
He J; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Material Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Yang J; NHC Key Laboratory of Biosynthesis of Natural Products, Institute of Material Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Li Y; Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Institute of Material Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. Electronic address: liyanxiao@imm.ac.cn.

Toxicol Appl Pharmacol ; 460: 116378, 2023 02 01.

Article en En | MEDLINE | ID: mdl-36641037

Asunto(s)

Ginsenósidos; Glioma; Ratones; Animales; Proteínas Proto-Oncogénicas c-akt/metabolismo; Ginsenósidos/farmacología; Fosfatidilinositol 3-Quinasas/metabolismo; Microambiente Tumoral; Transducción de Señal; Serina-Treonina Quinasas TOR/metabolismo; Glioma/metabolismo; Modelos Animales de Enfermedad; Receptores ErbB/metabolismo; Línea Celular Tumoral; Proliferación Celular

Palabras clave

EGFR/PI3K/AKT/mTOR signaling pathway; Ginsenoside 3ß-O-Glc-DM; Glioma; Tumor microenvironment

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Ginsenósidos / Glioma Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Toxicol Appl Pharmacol Año: 2023 Tipo del documento: Article País de afiliación: China

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