Systemic inflammatory markers and EEG features of children with FIRES receiving anakinra.
Ann Clin Transl Neurol
; 10(3): 440-446, 2023 03.
Article
en En
| MEDLINE
| ID: mdl-36645080
ABSTRACT
In a retrospective case series of 10 children with cryptogenic FIRES, we sought to describe the early clinical course and potential biomarkers following anakinra initiation. Six children achieved anesthetic withdrawal within 3 weeks of therapy and one in week four. Of the available cEEG (six children), CRP (10 children), and serum cytokine (six children) studies, there were temporal changes in highly epileptiform bursts (observed in three children), CRP, IL-6, and IL-10 levels that might parallel clinical progression. These observations may represent candidate biomarkers for monitoring clinical progression and therapeutic interventions including anakinra, which merits further investigation in future studies.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Citocinas
/
Proteína Antagonista del Receptor de Interleucina 1
Tipo de estudio:
Observational_studies
Límite:
Child
/
Humans
Idioma:
En
Revista:
Ann Clin Transl Neurol
Año:
2023
Tipo del documento:
Article
País de afiliación:
Estados Unidos