Epigenetic inheritance of gene silencing is maintained by a self-tuning mechanism based on resource competition.

Karin, Omer; Miska, Eric A; Simons, Benjamin D

Karin, Omer; Miska, Eric A; Simons, Benjamin D.

Afiliación

Karin O; Department of Applied Mathematics and Theoretical Physics, Centre for Mathematical Sciences, University of Cambridge, Cambridge, CB3 0WA, UK; Wellcome Trust, Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, CB2 1QN, UK; Department of Mathematics, Imperial College London, London, SW7 2AZ, UK. Electronic address: o.karin@imperial.ac.uk.
Miska EA; Wellcome Trust, Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, CB2 1QN, UK; Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK.
Simons BD; Department of Applied Mathematics and Theoretical Physics, Centre for Mathematical Sciences, University of Cambridge, Cambridge, CB3 0WA, UK; Wellcome Trust, Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, CB2 1QN, UK; Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, CB2 0AW, UK. Electronic address: bds10@cam.ac.uk.

Cell Syst ; 14(1): 24-40.e11, 2023 01 18.

Article en En | MEDLINE | ID: mdl-36657390

Asunto(s)

Proteínas de Caenorhabditis elegans; Epigénesis Genética; Animales; Epigénesis Genética/genética; Silenciador del Gen; Caenorhabditis elegans/genética; Caenorhabditis elegans/metabolismo; Proteínas de Caenorhabditis elegans/genética; Patrón de Herencia

Palabras clave

biological memory; design principles; dynamical systems; epigenetic memory; mathematical modeling; self organization; self-tuning to criticality; small RNAs; systems biology; transgenerational inheritance

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas de Caenorhabditis elegans / Epigénesis Genética Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Cell Syst Año: 2023 Tipo del documento: Article

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