Combining targeted DNA repair inhibition and immune-oncology approaches for enhanced tumor control.

Concannon, Kyle; Morris, Benjamin B; Gay, Carl M; Byers, Lauren A

Concannon, Kyle; Morris, Benjamin B; Gay, Carl M; Byers, Lauren A.

Afiliación

Concannon K; Department of Hematology/Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Morris BB; Department of Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Gay CM; Department of Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Byers LA; Department of Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: lbyers@mdanderson.org.

Mol Cell ; 83(5): 660-680, 2023 03 02.

Article en En | MEDLINE | ID: mdl-36669489

Asunto(s)

Daño del ADN; Neoplasias; Humanos; Neoplasias/genética; Reparación del ADN; Proteínas de la Ataxia Telangiectasia Mutada/genética

Palabras clave

ATR; DDRi-IO; DNA-damage repair; PARP; STING; biomarkers; cGAS-STING; cellular therapy; immune checkpoint blockade; immuno-oncology; mismatch repair deficits

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Daño del ADN / Neoplasias Límite: Humans Idioma: En Revista: Mol Cell Asunto de la revista: BIOLOGIA MOLECULAR Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos

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