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Malaria-driven expansion of adaptive-like functional CD56-negative NK cells correlates with clinical immunity to malaria.
Ty, Maureen; Sun, Shenghuan; Callaway, Perri C; Rek, John; Press, Kathleen D; van der Ploeg, Kattria; Nideffer, Jason; Hu, Zicheng; Klemm, Sandy; Greenleaf, William; Donato, Michele; Tukwasibwe, Stephen; Arinaitwe, Emmanuel; Nankya, Felistas; Musinguzi, Kenneth; Andrew, Dean; de la Parte, Lauren; Mori, Diego Martinez; Lewis, Savannah N; Takahashi, Saki; Rodriguez-Barraquer, Isabel; Greenhouse, Bryan; Blish, Catherine; Utz, P J; Khatri, Purvesh; Dorsey, Grant; Kamya, Moses; Boyle, Michelle; Feeney, Margaret; Ssewanyana, Isaac; Jagannathan, Prasanna.
Afiliación
  • Ty M; Department of Medicine, Stanford University, Stanford, CA, USA.
  • Sun S; Bakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA, USA.
  • Callaway PC; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
  • Rek J; Infectious Diseases Research Collaboration, Kampala, Uganda.
  • Press KD; Department of Medicine, Stanford University, Stanford, CA, USA.
  • van der Ploeg K; Department of Medicine, Stanford University, Stanford, CA, USA.
  • Nideffer J; Department of Medicine, Stanford University, Stanford, CA, USA.
  • Hu Z; Bakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA, USA.
  • Klemm S; Department of Genetics, Stanford University, Stanford, CA, USA.
  • Greenleaf W; Department of Genetics, Stanford University, Stanford, CA, USA.
  • Donato M; Institute for Immunity, Transplantation, and Infection, Stanford University, Stanford, CA, USA.
  • Tukwasibwe S; Infectious Diseases Research Collaboration, Kampala, Uganda.
  • Arinaitwe E; Infectious Diseases Research Collaboration, Kampala, Uganda.
  • Nankya F; Infectious Diseases Research Collaboration, Kampala, Uganda.
  • Musinguzi K; Infectious Diseases Research Collaboration, Kampala, Uganda.
  • Andrew D; Queensland Institute for Medical Research, Queensland, Australia.
  • de la Parte L; Department of Medicine, Stanford University, Stanford, CA, USA.
  • Mori DM; Department of Medicine, Stanford University, Stanford, CA, USA.
  • Lewis SN; Department of Medicine, Stanford University, Stanford, CA, USA.
  • Takahashi S; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
  • Rodriguez-Barraquer I; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
  • Greenhouse B; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
  • Blish C; Department of Medicine, Stanford University, Stanford, CA, USA.
  • Utz PJ; Chan Zuckerberg Biohub, San Francisco, CA, USA.
  • Khatri P; Department of Medicine, Stanford University, Stanford, CA, USA.
  • Dorsey G; Institute for Immunity, Transplantation, and Infection, Stanford University, Stanford, CA, USA.
  • Kamya M; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
  • Boyle M; Infectious Diseases Research Collaboration, Kampala, Uganda.
  • Feeney M; Department of Medicine, Makerere University, Kampala, Uganda.
  • Ssewanyana I; Queensland Institute for Medical Research, Queensland, Australia.
  • Jagannathan P; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Sci Transl Med ; 15(680): eadd9012, 2023 01 25.
Article en En | MEDLINE | ID: mdl-36696483
ABSTRACT
Natural killer (NK) cells likely play an important role in immunity to malaria, but the effect of repeated malaria on NK cell responses remains unclear. Here, we comprehensively profiled the NK cell response in a cohort of 264 Ugandan children. Repeated malaria exposure was associated with expansion of an atypical, CD56neg population of NK cells that differed transcriptionally, epigenetically, and phenotypically from CD56dim NK cells, including decreased expression of PLZF and the Fc receptor γ-chain, increased histone methylation, and increased protein expression of LAG-3, KIR, and LILRB1. CD56neg NK cells were highly functional and displayed greater antibody-dependent cellular cytotoxicity than CD56dim NK cells. Higher frequencies of CD56neg NK cells were associated with protection against symptomatic malaria and high parasite densities. After marked reductions in malaria transmission, frequencies of these cells rapidly declined, suggesting that continuous exposure to Plasmodium falciparum is required to maintain this modified, adaptive-like NK cell subset.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Células Asesinas Naturales / Malaria Límite: Child / Humans Idioma: En Revista: Sci Transl Med Asunto de la revista: CIENCIA / MEDICINA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Células Asesinas Naturales / Malaria Límite: Child / Humans Idioma: En Revista: Sci Transl Med Asunto de la revista: CIENCIA / MEDICINA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos