Insights into gene tissue specificity and protein-protein interactions in the context of purifying selection in humans.
Ann Hum Genet
; 87(1-2): 75-79, 2023 03.
Article
en En
| MEDLINE
| ID: mdl-36704895
ABSTRACT
BACKGROUND:
How much are natural selection and gene characteristics, such as the number of protein-protein interactions (PPIs), tissue specificity (ð½), and expression level, connected?METHODS:
In order to investigate these relationships, we combined different metrics linked to genetic constraints and analyzed their distribution concerning PPIs, ð½ and expression levels.RESULTS:
We discovered a positive correlation between genetic constraints, PPIs, and expression levels in all tissues. On the other hand, we obtained a negative correlation between genetic constraints and ð½. Furthermore, the fraction of variance in PPI and ð½ explained by the constraints metrics is around 6% and 10%, respectively.CONCLUSIONS:
We observed that the variance of expression of tissue-specific genes seems not related to their level of selection constraints, which is the opposite of what is found on non-tissue-specific genes. Overall these observations would help to elucidate the relationship between natural selection and gene features.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Selección Genética
Límite:
Humans
Idioma:
En
Revista:
Ann Hum Genet
Año:
2023
Tipo del documento:
Article
País de afiliación:
Italia