Expanding and improving nanobody repertoires using a yeast display method: Targeting SARS-CoV-2.

Cross, Frederick R; Fridy, Peter C; Ketaren, Natalia E; Mast, Fred D; Li, Song; Olivier, J Paul; Pecani, Kresti; Chait, Brian T; Aitchison, John D; Rout, Michael P

Cross, Frederick R; Fridy, Peter C; Ketaren, Natalia E; Mast, Fred D; Li, Song; Olivier, J Paul; Pecani, Kresti; Chait, Brian T; Aitchison, John D; Rout, Michael P.

Afiliación

Cross FR; Laboratory of Cell Cycle Genetics, The Rockefeller University, New York, New York, USA. Electronic address: fcross@rockefeller.edu.
Fridy PC; Laboratory of Cellular and Structural Biology, The Rockefeller University, New York, New York, USA.
Ketaren NE; Laboratory of Cellular and Structural Biology, The Rockefeller University, New York, New York, USA.
Mast FD; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, USA.
Li S; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, USA.
Olivier JP; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, USA.
Pecani K; Laboratory of Cell Cycle Genetics, The Rockefeller University, New York, New York, USA.
Chait BT; Laboratory of Mass Spectrometry and Gaseous Ion Chemistry, The Rockefeller University, New York, USA.
Aitchison JD; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, USA.
Rout MP; Laboratory of Cellular and Structural Biology, The Rockefeller University, New York, New York, USA. Electronic address: rout@rockefeller.edu.

J Biol Chem ; 299(3): 102954, 2023 03.

Article en En | MEDLINE | ID: mdl-36720309

Asunto(s)

Anticuerpos Neutralizantes; SARS-CoV-2; Anticuerpos de Dominio Único; Animales; Anticuerpos Neutralizantes/genética; Anticuerpos Antivirales/genética; Regiones Determinantes de Complementariedad; Saccharomyces cerevisiae/genética; SARS-CoV-2/genética; SARS-CoV-2/inmunología; Anticuerpos de Dominio Único/genética; Glicoproteína de la Espiga del Coronavirus/inmunología

Palabras clave

COVID-19; DNA shuffling; SARS-CoV-2; epitope binning; monoclonal antibodies; nanobodies; yeast display

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Anticuerpos Neutralizantes / Anticuerpos de Dominio Único / SARS-CoV-2 Límite: Animals Idioma: En Revista: J Biol Chem Año: 2023 Tipo del documento: Article

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