Sc-HOPO: A Potential Construct for Use in Radioscandium-Based Radiopharmaceuticals.
Inorg Chem
; 62(50): 20567-20581, 2023 Dec 18.
Article
en En
| MEDLINE
| ID: mdl-36724083
ABSTRACT
Three isotopes of scandiumâ43Sc, 44Sc, and 47Scâhave attracted increasing attention as potential candidates for use in imaging and therapy, respectively, as well as for possible theranostic use as an elementally matched pair. Here, we present the octadentate chelator 3,4,3-(LI-1,2-HOPO) (or HOPO), an effective chelator for hard cations, as a potential ligand for use in radioscandium constructs with simple radiolabeling under mild conditions. HOPO forms a 11 Sc-HOPO complex that was fully characterized, both experimentally and theoretically. [47Sc]Sc-HOPO exhibited good stability in chemical and biological challenges over 7 days. In healthy mice, [43,47Sc]Sc-HOPO cleared the body rapidly with no signs of demetalation. HOPO is a strong candidate for use in radioscandium-based radiopharmaceuticals.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Piridonas
/
Radiofármacos
Límite:
Animals
Idioma:
En
Revista:
Inorg Chem
Año:
2023
Tipo del documento:
Article
País de afiliación:
Estados Unidos