An Unusual Case of Low Vancomycin Exposure Despite Extremely High Vancomycin Doses Accompanied by Renal Toxicity: A Grand Round.
Ther Drug Monit
; 45(2): 136-139, 2023 04 01.
Article
en En
| MEDLINE
| ID: mdl-36728568
ABSTRACT: This grand round describes the case of a patient who received 10 grams (143.5 mg/kg) of vancomycin every 24 hours via continuous infusion, in whom the highest observed level was only 15.4 mg/L. Despite subtherapeutic levels, renal impairment was encountered, which resolved after the discontinuation of vancomycin. Glomerular hyperfiltration was found through nuclear glomerular filtration rate measurement, which likely explains the need for high doses (>6 grams per 24 hours continuous infusion) without reaching therapeutic serum levels.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Rondas de Enseñanza
/
Enfermedades Renales
Límite:
Humans
Idioma:
En
Revista:
Ther Drug Monit
Año:
2023
Tipo del documento:
Article