Discovery and optimization of olanzapine derivatives as new ferroptosis inhibitors.

Jiang, Xiufen; Teng, Xifeng; Shi, Huiwen; Cao, Liudan; He, Lin; Gu, Qiong

Jiang, Xiufen; Teng, Xifeng; Shi, Huiwen; Cao, Liudan; He, Lin; Gu, Qiong.

Afiliación

Jiang X; Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China; Guangdong Pharmaceutical University, Guangzhou 510006, People's Republic of China.
Teng X; Guangdong Pharmaceutical University, Guangzhou 510006, People's Republic of China; Key Laboratory of Lingnan Medicinal Materials Production and Development, National Administration of Traditional Chinese Medicine, Guangzhou 510006, People's Republic of China.
Shi H; Guangdong Pharmaceutical University, Guangzhou 510006, People's Republic of China.
Cao L; Guangdong Pharmaceutical University, Guangzhou 510006, People's Republic of China.
He L; Guangdong Pharmaceutical University, Guangzhou 510006, People's Republic of China; Guangdong Provincial Engineering and Technology Research Center of Cosmetics, Guangdong Pharmaceutical University, Zhongshan 528458, People's Republic of China. Electronic address: helin@gdpu.edu.cn.
Gu Q; Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China. Electronic address: guqiong@mail.sysu.edu.cn.

Bioorg Chem ; 133: 106393, 2023 04.

Article en En | MEDLINE | ID: mdl-36731296

Asunto(s)

Ferroptosis; Ratones; Humanos; Animales; Olanzapina/farmacología; Muerte Celular; Antioxidantes/farmacología

Palabras clave

Anti-oxidation; Ferroptosis inhibitor; Olanzapine; Structural modification

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Ferroptosis Límite: Animals / Humans Idioma: En Revista: Bioorg Chem Año: 2023 Tipo del documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google