Orally delivered single-domain antibodies against gastrointestinal pathogens.
Trends Biotechnol
; 41(7): 875-886, 2023 07.
Article
en En
| MEDLINE
| ID: mdl-36774206
ABSTRACT
Single-domain antibodies (sdAbs) are exceptionally stable fragments derived from the antigen-binding domains of immunoglobulins. They can withstand extreme pH, high temperature, and proteolysis, making them suitable for controlling gastrointestinal (GI) infections in humans and animals. sdAbs may function in their native soluble form, although different derived protein formats and the use of delivery vehicles can be useful for improved oral delivery. We discuss selected examples of the use of orally delivered sdAbs for protecting humans and animals against GI infections caused by pathogenic bacteria, viruses, and parasites. We finally provide perspectives on how sdAbs may be applied industrially and what challenges should be overcome for orally delivered sdAbs to reach the market.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Anticuerpos de Dominio Único
/
Enfermedades Gastrointestinales
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Trends Biotechnol
Año:
2023
Tipo del documento:
Article
País de afiliación:
Dinamarca