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Bacteroides ovatus alleviates dysbiotic microbiota-induced intestinal graft-versus-host disease.
Hayase, Eiko; Hayase, Tomo; Mukherjee, Akash; Stinson, Stuart C; Jamal, Mohamed A; Ortega, Miriam R; Sanchez, Christopher A; Ahmed, Saira S; Karmouch, Jennifer L; Chang, Chia-Chi; Flores, Ivonne I; McDaniel, Lauren K; Brown, Alexandria N; El-Himri, Rawan K; Chapa, Valerie A; Tan, Lin; Tran, Bao Q; Pham, Dung; Halsey, Taylor M; Jin, Yimei; Tsai, Wen-Bin; Prasad, Rishika; Glover, Israel K; Ajami, Nadim J; Wargo, Jennifer A; Shelburne, Samuel; Okhuysen, Pablo C; Liu, Chen; Fowler, Stephanie W; Conner, Margaret E; Peterson, Christine B; Rondon, Gabriela; Molldrem, Jeffrey J; Champlin, Richard E; Shpall, Elizabeth J; Lorenzi, Philip L; Mehta, Rohtesh S; Martens, Eric C; Alousi, Amin M; Jenq, Robert R.
Afiliación
  • Hayase E; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.
  • Hayase T; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.
  • Mukherjee A; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
  • Stinson SC; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
  • Jamal MA; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.
  • Ortega MR; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.
  • Sanchez CA; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.
  • Ahmed SS; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.
  • Karmouch JL; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.
  • Chang CC; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.
  • Flores II; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.
  • McDaniel LK; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.
  • Brown AN; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.
  • El-Himri RK; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.
  • Chapa VA; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.
  • Tan L; Metabolomics Core Facility, Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77230, USA.
  • Tran BQ; Metabolomics Core Facility, Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77230, USA.
  • Pham D; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.
  • Halsey TM; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.
  • Jin Y; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.
  • Tsai WB; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.
  • Prasad R; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.
  • Glover IK; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.
  • Ajami NJ; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.
  • Wargo JA; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.
  • Shelburne S; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.
  • Okhuysen PC; Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
  • Liu C; Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
  • Fowler SW; Department of Pathology, Yale School of Medicine, New Haven, Connecticut 06520, USA.
  • Conner ME; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA.
  • Peterson CB; Center for Comparative Medicine, Baylor College of Medicine, Houston, TX 77030, USA.
  • Rondon G; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA.
  • Molldrem JJ; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
  • Champlin RE; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
  • Shpall EJ; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
  • Lorenzi PL; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
  • Mehta RS; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
  • Martens EC; Metabolomics Core Facility, Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77230, USA.
  • Alousi AM; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
  • Jenq RR; Department of Microbiology & Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
Res Sq ; 2023 Jan 31.
Article en En | MEDLINE | ID: mdl-36778495
ABSTRACT
Acute gastrointestinal intestinal GVHD (aGI-GVHD) is a serious complication of allogeneic hematopoietic stem cell transplantation, and the intestinal microbiota is known to impact on its severity. However, an association between treatment response of aGI-GVHD and the intestinal microbiota has not been well-studied. In a cohort of patients with aGI-GVHD (n=37), we found that non-response to standard therapy with corticosteroids was associated with prior treatment with carbapenem antibiotics and loss of Bacteroides ovatus from the microbiome. In a mouse model of carbapenem-aggravated GVHD, introducing Bacteroides ovatus reduced severity of GVHD and improved survival. Bacteroides ovatus reduced degradation of colonic mucus by another intestinal commensal, Bacteroides thetaiotaomicron, via its ability to metabolize dietary polysaccharides into monosaccharides, which then inhibit mucus degradation by Bacteroides thetaiotaomicron and reduce GVHD-related mortality.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Res Sq Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Res Sq Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos