Induced epigenetic changes memorized across generations in mice.

Cheng, Saifeng; Mayshar, Yoav; Stelzer, Yonatan

Cheng, Saifeng; Mayshar, Yoav; Stelzer, Yonatan.

Afiliación

Cheng S; Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001 Rehovot, Israel.
Mayshar Y; Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001 Rehovot, Israel.
Stelzer Y; Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001 Rehovot, Israel. Electronic address: yonatan.stelzer@weizmann.ac.il.

Cell ; 186(4): 683-685, 2023 02 16.

Article en En | MEDLINE | ID: mdl-36803599

ABSTRACT

ABSTRACT

Transgenerational epigenetic inheritance in mammals has long been debatable. In this issue of Cell, Takahashi et al. induce DNA methylation at promoter-associated CpG islands (CGIs) of two metabolism-related genes and show that the acquired epigenetic changes and associated metabolic phenotypes are stably propagated across several generations in transgenic mice.

Asunto(s)

Metilación de ADN; Epigénesis Genética; Ratones; Animales; Mamíferos/genética; Patrón de Herencia; Islas de CpG/genética

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Metilación de ADN / Epigénesis Genética Límite: Animals Idioma: En Revista: Cell Año: 2023 Tipo del documento: Article País de afiliación: Israel

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