RNA epigenetic modifications in ovarian cancer: The changes, chances, and challenges.
Wiley Interdiscip Rev RNA
; 14(5): e1784, 2023.
Article
en En
| MEDLINE
| ID: mdl-36811232
ABSTRACT
Ovarian cancer (OC) is the most common female cancer worldwide. Patients with OC have high mortality because of its complex and poorly understood pathogenesis. RNA epigenetic modifications, such as m6 A, m1 A, and m5 C, are closely associated with the occurrence and development of OC. RNA modifications can affect the stability of mRNA transcripts, nuclear export of RNAs, translation efficiency, and decoding accuracy. However, there are few overviews that summarize the link between m6 A RNA modification and OC. Here, we discuss the molecular and cellular functions of different RNA modifications and how their regulation contributes to the pathogenesis of OC. By improving our understanding of the role of RNA modifications in the etiology of OC, we provide new perspectives for their use in OC diagnosis and treatment. This article is categorized under RNA Processing > RNA Editing and Modification RNA in Disease and Development > RNA in Disease.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias Ováricas
/
ARN
Límite:
Female
/
Humans
Idioma:
En
Revista:
Wiley Interdiscip Rev RNA
Año:
2023
Tipo del documento:
Article