Analysis of 3.5 million SARS-CoV-2 sequences reveals unique mutational trends with consistent nucleotide and codon frequencies.

Fumagalli, Sarah E; Padhiar, Nigam H; Meyer, Douglas; Katneni, Upendra; Bar, Haim; DiCuccio, Michael; Komar, Anton A; Kimchi-Sarfaty, Chava

Fumagalli, Sarah E; Padhiar, Nigam H; Meyer, Douglas; Katneni, Upendra; Bar, Haim; DiCuccio, Michael; Komar, Anton A; Kimchi-Sarfaty, Chava.

Afiliación

Fumagalli SE; Hemostasis Branch, Division of Plasma Protein Therapeutics, Office of Tissues and Advanced Therapies, Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA.
Padhiar NH; Hemostasis Branch, Division of Plasma Protein Therapeutics, Office of Tissues and Advanced Therapies, Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA.
Meyer D; Hemostasis Branch, Division of Plasma Protein Therapeutics, Office of Tissues and Advanced Therapies, Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA.
Katneni U; Hemostasis Branch, Division of Plasma Protein Therapeutics, Office of Tissues and Advanced Therapies, Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA.
Bar H; Department of Statistics, University of Connecticut, Storrs, CT, USA.
DiCuccio M; , Rockville, USA.
Komar AA; Department of Biological, Geological and Environmental Sciences, Center for Gene Regulation in Health and Disease, Cleveland State University, Cleveland, OH, USA.
Kimchi-Sarfaty C; Hemostasis Branch, Division of Plasma Protein Therapeutics, Office of Tissues and Advanced Therapies, Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA. Chava.kimchi-sarfaty@fda.hhs.gov.

Virol J ; 20(1): 31, 2023 02 17.

Article en En | MEDLINE | ID: mdl-36812119

Asunto(s)

COVID-19; Virus ARN; Humanos; SARS-CoV-2/genética; Nucleótidos; COVID-19/genética; Codón; Mutación; Genoma Viral; Virus ARN/genética; Evolución Molecular

Palabras clave

Codon adaptation index and dN/dS; Codon usage bias; Nucleotide usage; Relative synonymous codon usage; SARS-CoV-2

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Virus ARN / COVID-19 Límite: Humans Idioma: En Revista: Virol J Asunto de la revista: VIROLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos

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