Human coronavirus 3CL proteases cleave septins and disrupt Hedgehog signaling, causing ciliary dysfunction.

Lee, Ah Reum; Kweon, Yeong Cheon; Lee, Sang Min; Park, Chan Young

Lee, Ah Reum; Kweon, Yeong Cheon; Lee, Sang Min; Park, Chan Young.

Afiliación

Lee AR; Department of Biological Sciences, Ulsan National Institute of Science and Technology, Ulsan, Republic of Korea.
Kweon YC; Department of Biological Sciences, Ulsan National Institute of Science and Technology, Ulsan, Republic of Korea.
Lee SM; Department of Biological Sciences, Ulsan National Institute of Science and Technology, Ulsan, Republic of Korea.
Park CY; Department of Biological Sciences, Ulsan National Institute of Science and Technology, Ulsan, Republic of Korea.

J Med Virol ; 95(3): e28618, 2023 03.

Article en En | MEDLINE | ID: mdl-36840410

Asunto(s)

COVID-19; Septinas; Humanos; Septinas/genética; Septinas/metabolismo; Proteínas Hedgehog/metabolismo; Péptido Hidrolasas/metabolismo; Transducción de Señal; Endopeptidasas/metabolismo; Inhibidores de Proteasas/uso terapéutico

Palabras clave

3CL protease; HCoV-OC43; SARS-CoV-2; cilia; coronavirus; septin

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Septinas / COVID-19 Límite: Humans Idioma: En Revista: J Med Virol Año: 2023 Tipo del documento: Article

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