Analysis Of Inhibitory Effect Of Transcriptional Regulatory Protein (Sty 4289) Of Salmonella Typhi Ct18by Homology Modelling.
J Ayub Med Coll Abbottabad
; 35(1): 17-20, 2023.
Article
en En
| MEDLINE
| ID: mdl-36849370
ABSTRACT
BACKGROUND:
Salmonella typhi cause typhoid fever which is life threatening disease. It affects approximately 600,000 people per annum around the world. Food and water are the integral components through which this disease is transmitted and becomes base of typhoid. It spreads widely where cleanliness is very poor. Objective was to analyse three-dimensional structure of transcriptional regulator of Salmonella typhi CT18 by homology modelling to inhibit virulent effect of Salmonella typhi.METHODS:
Bioinformatics tools and programs like comprehensive Microbial resource (CMR). Interproscan, Basic Local Alignment Search tool (BLAST), Modeller 9.10, Procheck and Prosa were used as bioinformatic tools for effective study of protein.RESULTS:
Homology modelling is an appropriate and precise method to find three-dimensional transcriptional regulator to stop its virulency.CONCLUSIONS:
Homology modelling is computational and accurate method to find 3D structure of transcriptional regulator to inhibit its virulence effect of causing disease.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Salmonella typhi
/
Fiebre Tifoidea
Límite:
Humans
Idioma:
En
Revista:
J Ayub Med Coll Abbottabad
Asunto de la revista:
MEDICINA
Año:
2023
Tipo del documento:
Article
País de afiliación:
Pakistán