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Cryo-EM structure of amyloid fibril formed by α-synuclein hereditary A53E mutation reveals a distinct protofilament interface.
Sun, Chuanqi; Zhou, Kang; DePaola, Peter; Shin, Woo Shik; Hillyer, Trae; Sawaya, Michael R; Zhu, Ruowei; Peng, Chao; Zhou, Z Hong; Jiang, Lin.
Afiliación
  • Sun C; Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
  • Zhou K; Department of Microbiology, Immunology and Molecular Genetics, California Nano Systems Institute, UCLA, Los Angeles, CA, USA.
  • DePaola P; Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA; Departments of Biological Chemistry and Chemistry and Biochemistry, Howard Hughes Medical Institute, UCLA-DOE Institute, UCLA, Los Angeles, CA, USA.
  • Shin WS; Department of Pharmaceutical Sciences, College of Pharmacy, Northeast Ohio Medical University, Rootstown, OH, USA.
  • Hillyer T; Department of Pharmaceutical Sciences, College of Pharmacy, Northeast Ohio Medical University, Rootstown, OH, USA.
  • Sawaya MR; Departments of Biological Chemistry and Chemistry and Biochemistry, Howard Hughes Medical Institute, UCLA-DOE Institute, UCLA, Los Angeles, CA, USA.
  • Zhu R; Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
  • Peng C; Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
  • Zhou ZH; Department of Microbiology, Immunology and Molecular Genetics, California Nano Systems Institute, UCLA, Los Angeles, CA, USA.
  • Jiang L; Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA. Electronic address: jianglin@ucla.edu.
J Biol Chem ; 299(4): 104566, 2023 04.
Article en En | MEDLINE | ID: mdl-36871760
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Sinucleinopatías Límite: Humans Idioma: En Revista: J Biol Chem Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Sinucleinopatías Límite: Humans Idioma: En Revista: J Biol Chem Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos