Effects of curcumin/turmeric supplementation on obesity indices and adipokines in adults: A grade-assessed systematic review and dose-response meta-analysis of randomized controlled trials.
Phytother Res
; 37(4): 1703-1728, 2023 Apr.
Article
en En
| MEDLINE
| ID: mdl-36882287
ABSTRACT
In the present study, we explored the effect of curcumin/turmeric supplementation on anthropometric indices of obesity, leptin, and adiponectin. We searched PubMed, Scopus, Web of Science, Cochrane Library, and Google Scholar up to August 2022. Randomized clinical trials (RCTs) investigating the impact of curcumin/turmeric on obesity indices and adipokines were included. We applied the Cochrane quality assessment tool to evaluate the risk of bias. The registration number is CRD42022350946. Sixty eligible RCTs, with a total sample size of 3691 individuals were included for quantitative analysis. We found that supplementation with curcumin/turmeric significantly reduced body weight (WMD -0.82 kg, 95% CI -1.30, -0.35; p = 0.001), body mass index (WMD -0.30 kg/m2 , 95% CI -0.53, -0.06, p = 0.013), waist circumference (WMD -1.31 cm, 95% CI -1.94, -0.69, p < 0.001), body fat percentage (WMD -0.88%, 95% CI -1.51, -0.25, p = 0.007), leptin (WMD = -4.46 ng/mL; 95% CI -6.70, -2.21, p < 0.001), and increased adiponectin (WMD = 2.48 µg/mL; 95% CI 1.34, 3.62, p < 0.001). Overall, our study shows that supplementation with curcumin/turmeric significantly improves anthropometric indices of obesity and adiposity-related adipokines (leptin and adiponectin). However, due to high between-studies heterogeneity, we should interpret the results with caution.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Curcumina
Tipo de estudio:
Clinical_trials
/
Prognostic_studies
/
Systematic_reviews
Límite:
Adult
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Humans
Idioma:
En
Revista:
Phytother Res
Asunto de la revista:
TERAPIAS COMPLEMENTARES
Año:
2023
Tipo del documento:
Article
País de afiliación:
Irán