A single-arm, multicenter, phase II trial of osimertinib in patients with epidermal growth factor receptor exon 18 G719X, exon 20 S768I, or exon 21 L861Q mutations.

Villaruz, L C; Wang, X; Bertino, E M; Gu, L; Antonia, S J; Burns, T F; Clarke, J; Crawford, J; Evans, T L; Friedland, D M; Otterson, G A; Ready, N E; Wozniak, A J; Stinchcombe, T E

Villaruz, L C; Wang, X; Bertino, E M; Gu, L; Antonia, S J; Burns, T F; Clarke, J; Crawford, J; Evans, T L; Friedland, D M; Otterson, G A; Ready, N E; Wozniak, A J; Stinchcombe, T E.

Afiliación

Villaruz LC; UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh.
Wang X; Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham.
Bertino EM; Division of Medical Oncology, The Ohio State University James Comprehensive Cancer Center, Columbus.
Gu L; Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham.
Antonia SJ; Duke Cancer Institute, Durham, USA.
Burns TF; UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh.
Clarke J; Duke Cancer Institute, Durham, USA.
Crawford J; Duke Cancer Institute, Durham, USA.
Evans TL; UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh.
Friedland DM; UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh.
Otterson GA; Division of Medical Oncology, The Ohio State University James Comprehensive Cancer Center, Columbus.
Ready NE; Duke Cancer Institute, Durham, USA.
Wozniak AJ; UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh.
Stinchcombe TE; Duke Cancer Institute, Durham, USA. Electronic address: Thomas.stinchcombe@duke.edu.

ESMO Open ; 8(2): 101183, 2023 04.

Article en En | MEDLINE | ID: mdl-36905787

Asunto(s)

Carcinoma de Pulmón de Células no Pequeñas; Neoplasias Pulmonares; Humanos; Masculino; Femenino; Anciano; Carcinoma de Pulmón de Células no Pequeñas/tratamiento farmacológico; Carcinoma de Pulmón de Células no Pequeñas/genética; Carcinoma de Pulmón de Células no Pequeñas/patología; Neoplasias Pulmonares/tratamiento farmacológico; Neoplasias Pulmonares/genética; Neoplasias Pulmonares/patología; Inhibidores de Proteínas Quinasas/efectos adversos; Mutación; Receptores ErbB/genética; Exones/genética

Palabras clave

epidermal growth factor receptor mutation; non-small-cell lung cancer; osimertinib; targeted therapy; uncommon EGFR mutations

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Carcinoma de Pulmón de Células no Pequeñas / Neoplasias Pulmonares Tipo de estudio: Clinical_trials Límite: Aged / Female / Humans / Male Idioma: En Revista: ESMO Open Año: 2023 Tipo del documento: Article

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