An integrated approach of network pharmacology, molecular docking, and experimental verification uncovers kaempferol as the effective modulator of HSD17B1 for treatment of endometrial cancer.

Ruan, Guan-Yu; Ye, Li-Xiang; Lin, Jian-Song; Lin, Hong-Yu; Yu, Li-Rui; Wang, Cheng-Yan; Mao, Xiao-Dan; Zhang, Shui-Hua; Sun, Peng-Ming

Ruan, Guan-Yu; Ye, Li-Xiang; Lin, Jian-Song; Lin, Hong-Yu; Yu, Li-Rui; Wang, Cheng-Yan; Mao, Xiao-Dan; Zhang, Shui-Hua; Sun, Peng-Ming.

Afiliación

Ruan GY; Laboratory of Gynecologic Oncology, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Maternity and Child Health Hospital, Fujian Medical University, No. 18 Dao Shan Road, Fuzhou, 350001, Fujian, People's Republic of China.
Ye LX; Fujian Key Laboratory of Women and Children's Critical Diseases Research, Fujian Maternity and Child Health Hospital, Fuzhou, 350001, Fujian, People's Republic of China.
Lin JS; Fujian Clinical Research Center for Gynecologic Oncology, Fujian Maternity and Child Health Hospital (Fujian Obstetrics and Gynecology Hospital), Fuzhou, 350001, Fujian, People's Republic of China.
Lin HY; Fujian Center for Safety Evaluation of New Drugs, Fujian Medical University, No.1 Xue Fu Bei Road, University Town, Fuzhou, 350001, Fujian, People's Republic of China.
Yu LR; Department of Pathology, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Maternity and Child Health Hospital, Fujian Medical University, Fuzhou, 350001, Fujian, People's Republic of China.
Wang CY; Collage of Pharmacy, Fujian Medical University, Fuzhou, 351004, Fujian, People's Republic of China.
Mao XD; Laboratory of Gynecologic Oncology, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Maternity and Child Health Hospital, Fujian Medical University, No. 18 Dao Shan Road, Fuzhou, 350001, Fujian, People's Republic of China.
Zhang SH; Animal Research Institute, Fujian Medical University, Fuzhou, 351004, Fujian, People's Republic of China.
Sun PM; Laboratory of Gynecologic Oncology, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Maternity and Child Health Hospital, Fujian Medical University, No. 18 Dao Shan Road, Fuzhou, 350001, Fujian, People's Republic of China.

J Transl Med ; 21(1): 204, 2023 03 17.

Article en En | MEDLINE | ID: mdl-36932403

Asunto(s)

Neoplasias Endometriales; Estradiol Deshidrogenasas; Quempferoles; Farmacología en Red; Animales; Femenino; Humanos; Ratones; Línea Celular Tumoral; Proliferación Celular; Neoplasias Endometriales/tratamiento farmacológico; Neoplasias Endometriales/genética; Estrógenos/metabolismo; Quempferoles/farmacología; Simulación del Acoplamiento Molecular; PPAR gamma/metabolismo; Esteroides/metabolismo; Estradiol Deshidrogenasas/metabolismo

Palabras clave

Estrogen receptor α; HSD17B1; Human endometrial cancer; Kaempferol; Nude mice

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Endometriales / Quempferoles / Estradiol Deshidrogenasas / Farmacología en Red Límite: Animals / Female / Humans Idioma: En Revista: J Transl Med Año: 2023 Tipo del documento: Article

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