Neuroprotective methylsuccinic acid and enoic acid derivatives from the fungus Xylaria longipes.
Phytochemistry
; 210: 113652, 2023 Jun.
Article
en En
| MEDLINE
| ID: mdl-36967032
ABSTRACT
Three undescribed methylsuccinic acid derivatives, xylaril acids A-C, and two undescribed enoic acid derivatives, xylaril acids D-E, were isolated from the fungus Xylaria longipes. The structures of the undescribed compounds were deduced by spectroscopic means, including HRESIMS and 1D/2D NMR spectroscopy, as well as ECD calculations. The absolute configuration of xylaril acids A was further determined by single-crystal X-ray diffraction experiments. All the isolated compounds displayed neuroprotective activities against oxygen-glucose deprivation/reperfusion injury in PC12 cells by enhancing cell viability and inhibiting cell apoptosis.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Ascomicetos
/
Xylariales
Límite:
Animals
Idioma:
En
Revista:
Phytochemistry
Año:
2023
Tipo del documento:
Article