The role of Wnt signaling in the development of the epiblast and axial progenitors.
Curr Top Dev Biol
; 153: 145-180, 2023.
Article
en En
| MEDLINE
| ID: mdl-36967193
ABSTRACT
Understanding how the body plan is established during embryogenesis remains a fundamental biological question. The Wnt/ß-catenin signaling pathway plays a crucial and highly conserved role in body plan formation, functioning to polarize the primary anterior-posterior (AP) or head-to-tail body axis in most metazoans. In this chapter, we focus on the roles that the mammalian Wnt/ß-catenin pathway plays to prepare the pluripotent epiblast for gastrulation, and to elicit the emergence of multipotent axial progenitors from the caudal epiblast. Interactions between Wnt and retinoic acid (RA), another powerful family of developmental signaling molecules, in axial progenitors will also be discussed. Gastrulation movements and somitogenesis result in the anterior displacement of the RA source (the rostral somites and lateral plate mesoderm (LPM)), from the posterior Wnt source (the primitive streak (PS)), leading to the establishment of antiparallel gradients of RA and Wnt that control the self-renewal and successive differentiation of neck, trunk and tail progenitors.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Tipificación del Cuerpo
/
Vía de Señalización Wnt
Límite:
Animals
Idioma:
En
Revista:
Curr Top Dev Biol
Año:
2023
Tipo del documento:
Article
País de afiliación:
Estados Unidos