Independent study demonstrates amyloid probability score accurately indicates amyloid pathology.
Ann Clin Transl Neurol
; 10(5): 765-778, 2023 05.
Article
en En
| MEDLINE
| ID: mdl-36975407
ABSTRACT
BACKGROUND:
The amyloid probability score (APS) is the model read-out of the analytically validated mass spectrometry-based PrecivityAD® blood test that incorporates the plasma Aß42/40 ratio, ApoE proteotype, and age to identify the likelihood of brain amyloid plaques among cognitively impaired individuals being evaluated for Alzheimer's disease.PURPOSE:
This study aimed to provide additional independent evidence that the pre-established APS algorithm, along with its cutoff values, discriminates between amyloid positive and negative individuals.METHODS:
The diagnostic performance of the PrecivityAD test was analyzed in a cohort of 200 nonrandomly selected Australian Imaging, Biomarker & Lifestyle Flagship Study of Aging (AIBL) study participants, who were either cognitively impaired or healthy controls, and for whom a blood sample and amyloid PET imaging were available.RESULTS:
In a subset of the dataset aligned with the Intended Use population (patients aged 60 and older with CDR ≥0.5), the pre-established APS algorithm predicted amyloid PET with a sensitivity of 84.9% (CI 72.9-92.1%) and specificity of 96% (CI 80.5-99.3%), exclusive of 13 individuals for whom the test was inconclusive.INTERPRETATION:
The study shows individuals with a high APS are more likely than those with a low APS to have abnormal amounts of amyloid plaques and be on an amyloid accumulation trajectory, a dynamic and evolving process characteristic of progressive AD pathology. Exploratory data suggest APS retains its diagnostic performance in healthy individuals, supporting further screening studies in the cognitively unimpaired.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Péptidos beta-Amiloides
/
Enfermedad de Alzheimer
Tipo de estudio:
Prognostic_studies
Límite:
Aged
/
Humans
/
Middle aged
País/Región como asunto:
Oceania
Idioma:
En
Revista:
Ann Clin Transl Neurol
Año:
2023
Tipo del documento:
Article
País de afiliación:
Estados Unidos