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B13, a well-tolerated inhibitor of hedgehog pathway, exhibited potent anti-tumor effects against colorectal carcinoma in vitro and in vivo.
Wu, Huanxian; Zhang, Lishun; Chen, Boyu; Ou, Baofang; Xu, Jiahuan; Tian, Nannan; Yang, Danni; Ai, Yangcheng; Chen, Qianqing; Quan, Dongling; Zhang, Tingting; Lv, Lin; Tian, Yuanxin; Zhang, Jiajie; Wu, Shaoyu.
Afiliación
  • Wu H; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, Guangdong 510515, China; Clinical Pharmacy Center, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China.
  • Zhang L; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, Guangdong 510515, China; Department of Pharmacy, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510120, China.
  • Chen B; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, Guangdong 510515, China.
  • Ou B; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, Guangdong 510515, China; School of Pharmacy, Guangxi Medical University, Nanning, Guangxi 530021, China.
  • Xu J; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, Guangdong 510515, China.
  • Tian N; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, Guangdong 510515, China.
  • Yang D; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, Guangdong 510515, China; Pharmacy Department, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou 550001, China.
  • Ai Y; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, Guangdong 510515, China.
  • Chen Q; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, Guangdong 510515, China.
  • Quan D; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, Guangdong 510515, China; Integrated Traditional Chinese and Western Medicine Hospital of Southern Medical University, Guangzhou, Guangdong 510315, China.
  • Zhang T; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, Guangdong 510515, China.
  • Lv L; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, Guangdong 510515, China.
  • Tian Y; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, Guangdong 510515, China.
  • Zhang J; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, Guangdong 510515, China. Electronic address: zhangjj@smu.edu.cn.
  • Wu S; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, Guangdong 510515, China. Electronic address: wushaoyu@smu.edu.cn.
Bioorg Chem ; 135: 106488, 2023 06.
Article en En | MEDLINE | ID: mdl-36989734
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Proteínas Hedgehog Límite: Humans Idioma: En Revista: Bioorg Chem Año: 2023 Tipo del documento: Article País de afiliación: China
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Proteínas Hedgehog Límite: Humans Idioma: En Revista: Bioorg Chem Año: 2023 Tipo del documento: Article País de afiliación: China