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Partial recovery of neutrophil functions during prolonged hypothermia in pigs.
J Appl Physiol (1985) ; 60(4): 1186-9, 1986 Apr.
Article en En | MEDLINE | ID: mdl-3700301
The changes in circulation and migration of mature and immature neutrophils during 12 h of hypothermia have been studied using an experimental pig model. At 29 degrees C the number of circulating neutrophils fell from 5 +/- 1.1 at 37 degrees C to 3.5 +/- 0.6 X 10(9)/l and then remained unchanged while hypothermia was maintained. The number of circulating immature neutrophils did not fall during hypothermia. During hypothermia, hydrocortisone failed to stimulate the release of mature and immature neutrophils from the bone marrow. In contrast, endotoxin caused a profound neutropenia followed by a gradual increase in the number of circulating mature neutrophils, which by 6 h, was similar to the number circulating before endotoxin administration. At 29 degrees C the number of circulating immature neutrophils also fell following endotoxin but then increased over the number circulating before endotoxin administration by approximately 10-fold. Compared with neutrophil migration at 37 degrees C, very few mature or immature neutrophils migrated to an inflammatory site during the 12 h of hypothermia (29 degrees C). Unlike hypothermia in vitro, where neutrophil function may improve with time in vivo, neutrophil function remains compromised.
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Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Hipotermia / Neutrófilos Límite: Animals Idioma: En Revista: J Appl Physiol (1985) Asunto de la revista: FISIOLOGIA Año: 1986 Tipo del documento: Article
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Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Hipotermia / Neutrófilos Límite: Animals Idioma: En Revista: J Appl Physiol (1985) Asunto de la revista: FISIOLOGIA Año: 1986 Tipo del documento: Article