BC-1215 inhibits ATP-induced IL-1ß secretion via the FBXL2-mediated ubiquitination and degradation of not only NLRP3, but also pro-IL-1ß in LPS-primed THP-1 cells.

Jeon, Saemi; Kang, Junghoon; Lee, Seong-Beom

BC-1215 inhibits ATP-induced IL-1ß secretion via the FBXL2-mediated ubiquitination and degradation of not only NLRP3, but also pro-IL-1ß in LPS-primed THP-1 cells.

Jeon, Saemi; Kang, Junghoon; Lee, Seong-Beom.

Afiliación

Jeon S; Institute of Hansen's Disease, Department of Pathology, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, 06591, South Korea.
Kang J; Institute of Hansen's Disease, Department of Pathology, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, 06591, South Korea.
Lee SB; Institute of Hansen's Disease, Department of Pathology, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, 06591, South Korea. Electronic address: sblee@catholic.ac.kr.

Biochem Biophys Res Commun ; 657: 128-135, 2023 05 21.

Article en En | MEDLINE | ID: mdl-37004285

Asunto(s)

Proteínas F-Box; Proteína con Dominio Pirina 3 de la Familia NLR; Humanos; Adenosina Trifosfato/metabolismo; Caspasa 1/metabolismo; Proteínas F-Box/metabolismo; Inflamasomas/metabolismo; Interleucina-1beta/metabolismo; Lipopolisacáridos; Proteína con Dominio Pirina 3 de la Familia NLR/metabolismo; Células THP-1; Ubiquitinación

Palabras clave

BC-1215; FBXL2; FBXO3; NLRP3; Pro-IL-1ß; Ubiquitination

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas F-Box / Proteína con Dominio Pirina 3 de la Familia NLR Límite: Humans Idioma: En Revista: Biochem Biophys Res Commun Año: 2023 Tipo del documento: Article País de afiliación: Corea del Sur

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