Heart Failure Following Anti-Inflammatory Medications in Patients With Type 2 Diabetes Mellitus.
J Am Coll Cardiol
; 81(15): 1459-1470, 2023 04 18.
Article
en En
| MEDLINE
| ID: mdl-37045515
ABSTRACT
BACKGROUND:
Fluid retention and endothelial dysfunction have been related to use of nonsteroidal anti-inflammatory drugs (NSAIDs), and type 2 diabetes mellitus (T2DM) has been linked to both a decline in kidney function and subclinical cardiomyopathy.OBJECTIVES:
The authors hypothesized that short-term use of NSAIDs could lead to subsequent development of incident heart failure (HF) in patients with T2DM.METHODS:
Using nationwide Danish registers, we identified patients diagnosed with T2DM during 1998 to 2021 and included patients without previous HF, rheumatic disease, or use of NSAIDs 120 days before diagnosis. Associations between NSAIDs and first-time HF hospitalization were investigated using a case-crossover design with 28-day exposure windows, and ORs with 95% CIs were reported.RESULTS:
Included were 331,189 patients with T2DM 44.2% female, median age of 62 years (IQR 52-71 years); 23,308 patients were hospitalized with HF during follow-up, and 16% of patients claimed at least 1 NSAID prescription within 1 year. Short-term use of NSAIDs was associated with increased risk of HF hospitalization (OR 1.43; 95% CI 1.27-1.63), most notably in subgroups with age ≥80 years (OR 1.78; 95% CI 1.39-2.28), elevated hemoglobin (Hb) A1c levels treated with 0 to 1 antidiabetic drug (OR 1.68; 95% CI 1.00-2.88), and without previous use of NSAIDs (OR 2.71; 95% CI 1.78-4.23).CONCLUSIONS:
NSAIDs were widely used and were associated with an increased risk of first-time HF hospitalization in patients with T2DM. Patients with advanced age, elevated HbA1c levels, and new users of NSAID seemed more susceptible. These findings could guide physicians prescribing NSAIDs.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Enfermedades Vasculares
/
Diabetes Mellitus Tipo 2
/
Insuficiencia Cardíaca
Tipo de estudio:
Prognostic_studies
Límite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Am Coll Cardiol
Año:
2023
Tipo del documento:
Article