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EBD: an eye biomarker database.
Zhang, Xueli; Kong, Lingcong; Liu, Shunming; Zhang, Xiayin; Shang, Xianwen; Zhu, Zhuoting; Huang, Yu; Ma, Shuo; Jason, Ha; Kiburg, Katerina V; Zheng, Chunwen; Hu, Yunyan; Li, Cong; Wu, Guanrong; Liang, Yingying; He, Mengxia; Wang, Yan; Bai, Xiaohe; Shi, Danli; Wang, Wei; Zhang, Chi; Zhao, Ke; Yuan, Haining; Hu, Guang; Hu, Yijun; Liang, Huiying; Yu, Honghua; Zhang, Lei; He, Mingguang.
Afiliación
  • Zhang X; Department of Ophthalmology, Guangdong Eye Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, No. 106 Zhongshan Second Road, Guangzhou 510080, China.
  • Kong L; Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, No. 106 Zhongshan Second Road, Guangzhou 510080, China.
  • Liu S; Medical Big Data Center, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, No. 106 Zhongshan Second Road, Guangzhou 510080, China.
  • Zhang X; Department of Ophthalmology, Guangdong Eye Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, No. 106 Zhongshan Second Road, Guangzhou 510080, China.
  • Shang X; Department of Ophthalmology, Guangdong Eye Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, No. 106 Zhongshan Second Road, Guangzhou 510080, China.
  • Zhu Z; Department of Ophthalmology, Guangdong Eye Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, No. 106 Zhongshan Second Road, Guangzhou 510080, China.
  • Huang Y; Department of Ophthalmology, Guangdong Eye Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, No. 106 Zhongshan Second Road, Guangzhou 510080, China.
  • Ma S; Department of Ophthalmology, Guangdong Eye Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, No. 106 Zhongshan Second Road, Guangzhou 510080, China.
  • Jason H; Medical Big Data Center, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, No. 106 Zhongshan Second Road, Guangzhou 510080, China.
  • Kiburg KV; Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, 32 Gisborne Street, East Melbourne, VIC 3002, Australia.
  • Zheng C; Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, 32 Gisborne Street, East Melbourne, VIC 3002, Australia.
  • Hu Y; Department of Ophthalmology, Guangdong Eye Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, No. 106 Zhongshan Second Road, Guangzhou 510080, China.
  • Li C; Department of Ophthalmology, Guangdong Eye Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, No. 106 Zhongshan Second Road, Guangzhou 510080, China.
  • Wu G; Department of Ophthalmology, Guangdong Eye Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, No. 106 Zhongshan Second Road, Guangzhou 510080, China.
  • Liang Y; Department of Ophthalmology, Guangdong Eye Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, No. 106 Zhongshan Second Road, Guangzhou 510080, China.
  • He M; Department of Ophthalmology, Guangdong Eye Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, No. 106 Zhongshan Second Road, Guangzhou 510080, China.
  • Wang Y; Department of Ophthalmology, Guangdong Eye Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, No. 106 Zhongshan Second Road, Guangzhou 510080, China.
  • Bai X; Department of Ophthalmology, Guangdong Eye Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, No. 106 Zhongshan Second Road, Guangzhou 510080, China.
  • Shi D; Department of Mathematics, University of California, 9500 Gilman Dr, La Jolla, San Diego, CA 92093, United States.
  • Wang W; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, No. 54 Xianlie South Road, Guangzhou 510060, China.
  • Zhang C; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, No. 54 Xianlie South Road, Guangzhou 510060, China.
  • Zhao K; Department of Otolaryngology, Guangzhou Women and Children's Medical Centre, No. 9 Jinsui Road, Guangzhou 510623, China.
  • Yuan H; Department of Radiology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, No. 106 Zhongshan Second Road, Guangzhou 510080, China.
  • Hu G; HangZhou Medical College, No. 8 Jikang Street, Lin'an District, Hangzhou 311399, China.
  • Hu Y; Department of Bioinformatics, Center for Systems Biology, School of Biology and Basic Medical Sciences, Soochow University, No. 199 Ren'ai Road, Suzhou Industrial Park, Suzhou 215123, China.
  • Liang H; Department of Ophthalmology, Guangdong Eye Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, No. 106 Zhongshan Second Road, Guangzhou 510080, China.
  • Yu H; Medical Big Data Center, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, No. 106 Zhongshan Second Road, Guangzhou 510080, China.
  • Zhang L; Department of Ophthalmology, Guangdong Eye Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, No. 106 Zhongshan Second Road, Guangzhou 510080, China.
  • He M; Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, 32 Gisborne Street, East Melbourne, VIC 3002, Australia.
Bioinformatics ; 39(5)2023 05 04.
Article en En | MEDLINE | ID: mdl-37052519
ABSTRACT
MOTIVATION Many ophthalmic disease biomarkers have been identified through comprehensive multiomics profiling, and hold significant potential in advancing the diagnosis, prognosis, and management of diseases. Meanwhile, the eye itself serves as a natural biomarker for several systemic diseases including neurological, renal, and cardiovascular systems. We aimed to collect and standardize this eye biomarkers information and construct the eye biomarker database (EBD) to provide ophthalmologists with a platform to search, analyze, and download these eye biomarker data.

RESULTS:

In this study, we present the EBD , a world-first online compilation comprising 889 biomarkers for 26 ocular diseases and 939 eye biomarkers for 181 systemic diseases. The EBD also includes the information of 78 "nonbiomarkers"-the objects that have been proven cannot be biomarkers. Biological function and network analysis were conducted for these ocular disease biomarkers, and several hub pathways and common network topology characteristics were newly identified, which may promote future ocular disease biomarker discovery and characterizes the landscape of biomarkers for eye diseases at the pathway and network level. The EBD is expected to yield broader utility among developmental biologists and clinical scientists in and outside of the eye field by assisting in the identification of biomarkers linked to eye disorders and related systemic diseases. AVAILABILITY AND IMPLEMENTATION EBD is available at http//www.eyeseeworld.com/ebd/index.html.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Investigación Biomédica Tipo de estudio: Prognostic_studies Idioma: En Revista: Bioinformatics Asunto de la revista: INFORMATICA MEDICA Año: 2023 Tipo del documento: Article País de afiliación: China
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Investigación Biomédica Tipo de estudio: Prognostic_studies Idioma: En Revista: Bioinformatics Asunto de la revista: INFORMATICA MEDICA Año: 2023 Tipo del documento: Article País de afiliación: China