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Pomiferin targets SERCA, mTOR, and P-gp to induce autophagic cell death in apoptosis-resistant cancer cells, and reverses the MDR phenotype in cisplatin-resistant tumors in vivo.
Qu, Yuan-Qing; Song, Lin-Lin; Xu, Su-Wei; Yu, Margaret Sum Yee; Kadioglu, Onat; Michelangeli, Francesco; Law, Betty Yuen Kwan; Efferth, Thomas; Lam, Christopher Wai-Kei; Wong, Vincent Kam Wai.
Afiliación
  • Qu YQ; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau; Faculty of Medicine, Macau University of Science and Technology, Macau.
  • Song LL; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau.
  • Xu SW; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau; Department of Basic Medicine of Zhuhai Health School, Zhuhai, China.
  • Yu MSY; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau.
  • Kadioglu O; Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, Mainz 55128, Germany.
  • Michelangeli F; Department of Biological Sciences, University of Chester, Chester, UK.
  • Law BYK; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau.
  • Efferth T; Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, Mainz 55128, Germany.
  • Lam CW; Faculty of Medicine, Macau University of Science and Technology, Macau. Electronic address: wklam@must.edu.mo.
  • Wong VKW; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau. Electronic address: kawwong@must.edu.mo.
Pharmacol Res ; 191: 106769, 2023 05.
Article en En | MEDLINE | ID: mdl-37061145
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Muerte Celular Autofágica / Neoplasias Pulmonares / Antineoplásicos Límite: Animals Idioma: En Revista: Pharmacol Res Asunto de la revista: FARMACOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Macao
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Muerte Celular Autofágica / Neoplasias Pulmonares / Antineoplásicos Límite: Animals Idioma: En Revista: Pharmacol Res Asunto de la revista: FARMACOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Macao