Ago2 and a miRNA reduce Topoisomerase 1 for enhancing DNA cleavage in antibody diversification by activation-induced cytidine deaminase.

Kobayashi, Maki; Wakaguri, Hiroyuki; Shimizu, Masakazu; Higasa, Koichiro; Matsuda, Fumihiko; Honjo, Tasuku

Kobayashi, Maki; Wakaguri, Hiroyuki; Shimizu, Masakazu; Higasa, Koichiro; Matsuda, Fumihiko; Honjo, Tasuku.

Afiliación

Kobayashi M; Immunology and Genomic Medicine, Center for Cancer Immunotherapy and Immunobiology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.
Wakaguri H; Center for Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.
Shimizu M; Center for Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.
Higasa K; Center for Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.
Matsuda F; Center for Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.
Honjo T; Immunology and Genomic Medicine, Center for Cancer Immunotherapy and Immunobiology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.

Proc Natl Acad Sci U S A ; 120(18): e2216918120, 2023 05 02.

Article en En | MEDLINE | ID: mdl-37094168

Asunto(s)

MicroARNs; MicroARNs/genética; Regiones no Traducidas 3'; División del ADN; Citidina Desaminasa/genética; Cambio de Clase de Inmunoglobulina; Anticuerpos/genética; Hipermutación Somática de Inmunoglobulina

Palabras clave

RISC; genome instability; immunological memory; miRNA

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: MicroARNs Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2023 Tipo del documento: Article País de afiliación: Japón

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