Exploiting conformational dynamics to modulate the function of designed proteins.

Rennella, Enrico; Sahtoe, Danny D; Baker, David; Kay, Lewis E

Rennella, Enrico; Sahtoe, Danny D; Baker, David; Kay, Lewis E.

Afiliación

Rennella E; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.
Sahtoe DD; Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada.
Baker D; Department of Chemistry, University of Toronto, Toronto, ON M5S 3H6, Canada.
Kay LE; Department of Biochemistry, University of Washington, Seattle, WA 98195.

Proc Natl Acad Sci U S A ; 120(18): e2303149120, 2023 05 02.

Article en En | MEDLINE | ID: mdl-37094170

Asunto(s)

Inteligencia Artificial; Proteínas; Conformación Proteica; Secuencia de Aminoácidos; Péptidos; Ligandos

Palabras clave

NMR spectroscopy; chemical exchange saturation transfer; conformational dynamics; ligand binding; protein design

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Inteligencia Artificial / Proteínas Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2023 Tipo del documento: Article País de afiliación: Canadá

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