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Apoptotic cell death in disease-Current understanding of the NCCD 2023.
Vitale, Ilio; Pietrocola, Federico; Guilbaud, Emma; Aaronson, Stuart A; Abrams, John M; Adam, Dieter; Agostini, Massimiliano; Agostinis, Patrizia; Alnemri, Emad S; Altucci, Lucia; Amelio, Ivano; Andrews, David W; Aqeilan, Rami I; Arama, Eli; Baehrecke, Eric H; Balachandran, Siddharth; Bano, Daniele; Barlev, Nickolai A; Bartek, Jiri; Bazan, Nicolas G; Becker, Christoph; Bernassola, Francesca; Bertrand, Mathieu J M; Bianchi, Marco E; Blagosklonny, Mikhail V; Blander, J Magarian; Blandino, Giovanni; Blomgren, Klas; Borner, Christoph; Bortner, Carl D; Bove, Pierluigi; Boya, Patricia; Brenner, Catherine; Broz, Petr; Brunner, Thomas; Damgaard, Rune Busk; Calin, George A; Campanella, Michelangelo; Candi, Eleonora; Carbone, Michele; Carmona-Gutierrez, Didac; Cecconi, Francesco; Chan, Francis K-M; Chen, Guo-Qiang; Chen, Quan; Chen, Youhai H; Cheng, Emily H; Chipuk, Jerry E; Cidlowski, John A; Ciechanover, Aaron.
Afiliación
  • Vitale I; IIGM - Italian Institute for Genomic Medicine, c/o IRCSS Candiolo, Torino, Italy. iliovit@gmail.com.
  • Pietrocola F; Candiolo Cancer Institute, FPO -IRCCS, Candiolo, Italy. iliovit@gmail.com.
  • Guilbaud E; Department of Biosciences and Nutrition, Karolinska Institute, Huddinge, Sweden.
  • Aaronson SA; Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA.
  • Abrams JM; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
  • Adam D; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
  • Agostini M; Institut für Immunologie, Kiel University, Kiel, Germany.
  • Agostinis P; Department of Experimental Medicine, University of Rome Tor Vergata, TOR, Rome, Italy.
  • Alnemri ES; Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.
  • Altucci L; VIB Center for Cancer Biology, Leuven, Belgium.
  • Amelio I; Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA, USA.
  • Andrews DW; Department of Precision Medicine, University of Campania Luigi Vanvitelli, Naples, Italy.
  • Aqeilan RI; BIOGEM, Avellino, Italy.
  • Arama E; Division of Systems Toxicology, Department of Biology, University of Konstanz, Konstanz, Germany.
  • Baehrecke EH; Sunnybrook Research Institute, Toronto, ON, Canada.
  • Balachandran S; Departments of Biochemistry and Medical Biophysics, University of Toronto, Toronto, ON, Canada.
  • Bano D; Hebrew University of Jerusalem, Lautenberg Center for Immunology & Cancer Research, Institute for Medical Research Israel-Canada (IMRIC), Faculty of Medicine, Jerusalem, Israel.
  • Barlev NA; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
  • Bartek J; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
  • Bazan NG; Blood Cell Development and Function Program, Fox Chase Cancer Center, Philadelphia, PA, USA.
  • Becker C; Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany.
  • Bernassola F; Department of Biomedicine, Nazarbayev University School of Medicine, Astana, Kazakhstan.
  • Bertrand MJM; Department of Medical Biochemistry and Biophysics, Science for Life Laboratory, Karolinska Institute, Stockholm, Sweden.
  • Bianchi ME; Danish Cancer Society Research Center, Copenhagen, Denmark.
  • Blagosklonny MV; Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health New Orleans, New Orleans, LA, USA.
  • Blander JM; Department of Medicine 1, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany.
  • Blandino G; Department of Experimental Medicine, University of Rome Tor Vergata, TOR, Rome, Italy.
  • Blomgren K; VIB-UGent Center for Inflammation Research, Ghent, Belgium.
  • Borner C; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.
  • Bortner CD; Università Vita-Salute San Raffaele, School of Medicine, Milan, Italy and Ospedale San Raffaele IRCSS, Milan, Italy.
  • Bove P; Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
  • Boya P; Department of Medicine, Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, New York, NY, USA.
  • Brenner C; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA.
  • Broz P; Sandra and Edward Meyer Cancer Center, New York, NY, USA.
  • Brunner T; IRCSS Regina Elena National Cancer Institute, Rome, Italy.
  • Damgaard RB; Department of Women's and Children's Health, Karolinska Institute, Stockholm, Sweden.
  • Calin GA; Pediatric Hematology and Oncology, Karolinska University Hospital, Stockholm, Sweden.
  • Campanella M; Institute of Molecular Medicine and Cell Research, Medical Faculty, Albert Ludwigs University of Freiburg, Freiburg, Germany.
  • Candi E; Signal Transduction Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, Durham, NC, USA.
  • Carbone M; Department of Experimental Medicine, University of Rome Tor Vergata, TOR, Rome, Italy.
  • Carmona-Gutierrez D; Centro de Investigaciones Biologicas Margarita Salas, CSIC, Madrid, Spain.
  • Cecconi F; Université Paris-Saclay, CNRS, Institut Gustave Roussy, Aspects métaboliques et systémiques de l'oncogénèse pour de nouvelles approches thérapeutiques, Villejuif, France.
  • Chan FK; Department of Immunobiology, University of Lausanne, Epalinges, Vaud, Switzerland.
  • Chen GQ; Department of Biology, University of Konstanz, Konstanz, Germany.
  • Chen Q; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.
  • Chen YH; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Cheng EH; Center for RNA Interference and Non-Coding RNAs, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Chipuk JE; Department of Comparative Biomedical Sciences, The Royal Veterinary College, University of London, London, UK.
  • Cidlowski JA; UCL Consortium for Mitochondrial Research, London, UK.
  • Ciechanover A; Department of Biology, University of Rome Tor Vergata, Rome, Italy.
Cell Death Differ ; 30(5): 1097-1154, 2023 05.
Article en En | MEDLINE | ID: mdl-37100955
ABSTRACT
Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in mammalian systems have elucidated the key contribution of this process not only to (post-)embryonic development and adult tissue homeostasis, but also to the etiology of multiple human disorders. Consistent with this notion, while defects in the molecular machinery for apoptotic cell death impair organismal development and promote oncogenesis, the unwarranted activation of apoptosis promotes cell loss and tissue damage in the context of various neurological, cardiovascular, renal, hepatic, infectious, neoplastic and inflammatory conditions. Here, the Nomenclature Committee on Cell Death (NCCD) gathered to critically summarize an abundant pre-clinical literature mechanistically linking the core apoptotic apparatus to organismal homeostasis in the context of disease.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Apoptosis / Caspasas Límite: Animals / Humans Idioma: En Revista: Cell Death Differ Año: 2023 Tipo del documento: Article País de afiliación: Italia
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Apoptosis / Caspasas Límite: Animals / Humans Idioma: En Revista: Cell Death Differ Año: 2023 Tipo del documento: Article País de afiliación: Italia