Intestinal bile acids provide a surmountable barrier against <i>C. difficile</i> TcdB-induced disease pathogenesis.

Icho, Simoun; Ward, Jennifer S; Tam, John; Kociolek, Larry K; Theriot, Casey M; Melnyk, Roman A

Intestinal bile acids provide a surmountable barrier against C. difficile TcdB-induced disease pathogenesis.

Icho, Simoun; Ward, Jennifer S; Tam, John; Kociolek, Larry K; Theriot, Casey M; Melnyk, Roman A.

Afiliación

Icho S; Molecular Medicine Program, The Hospital for Sick Children Research Institute, Toronto, ON M5G 0A4.
Ward JS; Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8.
Tam J; Molecular Medicine Program, The Hospital for Sick Children Research Institute, Toronto, ON M5G 0A4.
Kociolek LK; Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8.
Theriot CM; Molecular Medicine Program, The Hospital for Sick Children Research Institute, Toronto, ON M5G 0A4.
Melnyk RA; Ann & Robert H. Lurie, Children's Hospital of Chicago, Chicago, IL 60611.

Proc Natl Acad Sci U S A ; 120(19): e2301252120, 2023 05 09.

Article en En | MEDLINE | ID: mdl-37126691

Asunto(s)

Toxinas Bacterianas; Clostridioides difficile; Infecciones por Clostridium; Humanos; Ratones; Animales; Ácidos y Sales Biliares; Infecciones por Clostridium/patología; Intestinos/patología; Proteínas Bacterianas

Palabras clave

C. difficile; Host; Toxin; bile acid; pathogenesis

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Toxinas Bacterianas / Clostridioides difficile / Infecciones por Clostridium Tipo de estudio: Etiology_studies Límite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2023 Tipo del documento: Article

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