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Prevalence and characteristics of subclinical giant cell arteritis in polymyalgia rheumatica.
De Miguel, Eugenio; Macchioni, Pierluigi; Conticini, Edoardo; Campochiaro, Corrado; Karalilova, Rositsa; Monti, Sara; Ponte, Cristina; Klinowski, Giulia; Monjo-Henry, Irene; Falsetti, Paolo; Batalov, Zguro; Tomelleri, Alessandro; Hocevar, Alojzija.
Afiliación
  • De Miguel E; Rheumatology Department, Hospital Universitario La Paz, Madrid, Spain.
  • Macchioni P; Department of Rheumatology, IRCCS-S.Maria Nuova, Reggio Emilia, Italy.
  • Conticini E; Rheumatology Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.
  • Campochiaro C; Unit of Immunology, Rheumatology Department, Allergy and Rare Diseases (UnIRAR), San Raffaele Scientific Institute, Milan, Italy.
  • Karalilova R; Rheumatology Department, Medical University of Plovdiv, University Hospital Kaspela, Plovdiv, Bulgaria.
  • Monti S; Department of Rheumatology, IRCCS Policlinico S Matteo Fondazione, University of Pavia, Pavia, Italy.
  • Ponte C; Rheumatology Department, Hospital de Santa Maria, Centro Hospitalar Universitario Lisboa Norte EPE, Lisboa, Portugal.
  • Klinowski G; Department of Rheumatology, IRCCS-S.Maria Nuova, Reggio Emilia, Italy.
  • Monjo-Henry I; Rheumatology Department, Hospital Universitario La Paz, Madrid, Spain.
  • Falsetti P; Rheumatology Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.
  • Batalov Z; Rheumatology Department, Medical University of Plovdiv, University Hospital Kaspela, Plovdiv, Bulgaria.
  • Tomelleri A; Unit of Immunology, Rheumatology Department, Allergy and Rare Diseases (UnIRAR), San Raffaele Scientific Institute, Milan, Italy.
  • Hocevar A; Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia.
Rheumatology (Oxford) ; 63(1): 158-164, 2024 Jan 04.
Article en En | MEDLINE | ID: mdl-37129541
OBJECTIVE: The main objective of this study was to analyse the prevalence and characteristics of subclinical GCA in patients with PMR. METHODS: This was a cross-sectional multicentre international study of consecutive patients with newly diagnosed PMR without symptoms or signs suggestive of GCA. All patients underwent US of the temporal superficial, common carotid, subclavian and axillary arteries. Patients with halo signs in at least one examined artery were considered to have subclinical GCA. The clinical, demographic and laboratory characteristics of the PMR group without subclinical vasculitis were compared with subclinical GCA, and the pattern of vessel involvement was compared with that of a classical single-centre GCA cohort. RESULTS: We included 346 PMR patients, 267 (77.2%) without subclinical GCA and 79 (22.8%) with subclinical GCA. The PMR patients with subclinical GCA were significantly older, had a longer duration of morning stiffness and more frequently reported hip pain than PMR without subclinical GCA. PMR with subclinical GCA showed a predominant extracranial large vessel pattern of vasculitic involvement compared with classical GCA, where the cranial phenotype predominated. The patients with PMR in the classical GCA group showed a pattern of vessel involvement similar to classical GCA without PMR but different from PMR with subclinical involvement. CONCLUSION: More than a fifth of the pure PMR patients had US findings consistent with subclinical GCA. This specific subset of patients showed a predilection for extracranial artery involvement. The optimal screening strategy to assess the presence of vasculitis in PMR remains to be determined.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Polimialgia Reumática / Arteritis de Células Gigantes Tipo de estudio: Prevalence_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Rheumatology (Oxford) Asunto de la revista: REUMATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: España

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Polimialgia Reumática / Arteritis de Células Gigantes Tipo de estudio: Prevalence_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Rheumatology (Oxford) Asunto de la revista: REUMATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: España