Mutations in &#945;-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases.

Sampognaro, Paul J; Arya, Shruti; Knudsen, Giselle M; Gunderson, Emma L; Sandoval-Perez, Angelica; Hodul, Molly; Bowles, Kathryn; Craik, Charles S; Jacobson, Matthew P; Kao, Aimee W

Mutations in α-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases.

Sampognaro, Paul J; Arya, Shruti; Knudsen, Giselle M; Gunderson, Emma L; Sandoval-Perez, Angelica; Hodul, Molly; Bowles, Kathryn; Craik, Charles S; Jacobson, Matthew P; Kao, Aimee W.

Afiliación

Sampognaro PJ; Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.
Arya S; Neuromuscular Division, Department of Neurology, University of California, San Francisco, CA, USA.
Knudsen GM; Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.
Gunderson EL; Alaunus Biosciences, Inc., South San Francisco, CA, USA.
Sandoval-Perez A; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA.
Hodul M; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA.
Bowles K; Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.
Craik CS; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, USA.
Jacobson MP; UK Dementia Research Institute at the University of Edinburgh, Edinburgh Medical School, Edinburgh, UK.
Kao AW; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA.

Mol Neurodegener ; 18(1): 29, 2023 05 02.

Article en En | MEDLINE | ID: mdl-37131250

Asunto(s)

Proteínas de Unión al ADN; Enfermedades Neurodegenerativas; alfa-Sinucleína; Humanos; alfa-Sinucleína/genética; alfa-Sinucleína/metabolismo; Proteínas de Unión al ADN/genética; Proteínas de Unión al ADN/metabolismo; Semivida; Lisosomas/metabolismo; Mutación/genética; Enfermedades Neurodegenerativas/metabolismo; Péptido Hidrolasas/metabolismo; Proteínas tau/genética; Proteínas tau/metabolismo

Palabras clave

Autophagy; Cathepsin; Lysosome; Mutations; Neurodegeneration; Protease; TDP-43; Tau; α-synuclein

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfermedades Neurodegenerativas / Proteínas de Unión al ADN / Alfa-Sinucleína Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Mol Neurodegener Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos

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